CPLM-009545

Genbank Nucleotide ID

40S ribosomal protein S6

Protein Synonyms/Alias

Mus musculus (Mouse)

Position	Peptide	Type	References
2	******MKLNISFPA	acetylation	[1]
14	FPATGCQKLIEVDDE	acetylation	[1]
30	KLRTFYEKRMATEVA	acetylation	[1]
58	RISGGNDKQGFPMKQ	acetylation	[1]
58	RISGGNDKQGFPMKQ	ubiquitination	[2]
119	VIVKKGEKDIPGLTD	acetylation	[3, 4]
143	KRASRIRKLFNLSKE	acetylation	[5]
143	KRASRIRKLFNLSKE	ubiquitination	[2]
149	RKLFNLSKEDDVRQY	acetylation	[5]
203	KQRTKKNKEEAAEYA	acetylation	[3, 4, 6]
211	EEAAEYAKLLAKRMK	acetylation	[4, 5, 6, 7, 8]
211	EEAAEYAKLLAKRMK	ubiquitination	[2]

[1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
[2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
[4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
[5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
[6] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
Simon GM, Cheng J, Gordon JI.
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
[7] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
PLoS One. 2012;7(12):e50545. [PMID: 23236377]
[8] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]

Functional Description

May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.

MOD_RES 211 211 N6-acetyllysine (By similarity).
MOD_RES 235 235 Phosphoserine; by RPS6KA1, RPS6KA3, DAPK1
MOD_RES 236 236 Phosphoserine; by RPS6KA1, RPS6KA3, DAPK1
MOD_RES 240 240 Phosphoserine.
MOD_RES 242 242 Phosphoserine (By similarity).
MOD_RES 244 244 Phosphoserine.
MOD_RES 246 246 Phosphoserine.
MOD_RES 247 247 Phosphoserine.

Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005730; C:nucleolus; IEA:Compara.
GO:0015935; C:small ribosomal subunit; IEA:Compara.
GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
GO:0042593; P:glucose homeostasis; IDA:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
GO:0042274; P:ribosomal small subunit biogenesis; IEA:Compara.
GO:0006364; P:rRNA processing; IEA:Compara.
GO:0031929; P:TOR signaling cascade; IEA:Compara.
GO:0006412; P:translation; IEA:InterPro.

IPR014401; Ribosomal_S6_euk.
IPR001377; Ribosomal_S6e.
IPR018282; Ribosomal_S6e_CS.

PF01092; Ribosomal_S6e

PS00578; RIBOSOMAL_S6E