UniProt Accession

 ZN496_HUMAN; Q96IT1; Q8TBS2 

Genbank Protein ID

 AC104335; BC007263; BC025794 

Genbank Nucleotide ID

 AAH07263.1; AAH25794.1 

Protein Name

 Zinc finger protein 496 

Protein Synonyms/Alias

 Zinc finger protein with KRAB and SCAN domains 17 

Gene Name

 ZNF496 

Gene Synonyms/Alias

 ZKSCAN17 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
13	CPRVLAPKESEEPRK	ubiquitination	[1]
289	ELQDLQGKEVPQVSY	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 DNA-binding transcription factor that can both act as an activator and a repressor (By similarity). 

Sequence Annotation

 DOMAIN 42 124 SCAN box.
 DOMAIN 221 291 KRAB.
 ZN_FING 406 428 C2H2-type 1; degenerate.
 ZN_FING 435 457 C2H2-type 2.
 ZN_FING 463 485 C2H2-type 3.
 ZN_FING 522 545 C2H2-type 4.
 ZN_FING 553 575 C2H2-type 5.
 MOD_RES 185 185 Phosphoserine.
 MOD_RES 299 299 Phosphoserine.  

Keyword

 Activator; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 587 AA 

Protein Sequence

Gene Ontology

 GO:0016604; C:nuclear body; IEA:Compara.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0003677; F:DNA binding; ISS:UniProtKB.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IBA:RefGenome.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0016032; P:viral reproduction; IEA:InterPro. 

Interpro

 IPR001909; Krueppel-associated_box.
 IPR008916; Retrov_capsid_C.
 IPR003309; Tscrpt_reg_SCAN.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF01352; KRAB
 PF02023; SCAN
 PF00096; zf-C2H2 

SMART

 SM00349; KRAB
 SM00431; SCAN
 SM00355; ZnF_C2H2 

PROSITE

 PS50805; KRAB
 PS50804; SCAN_BOX
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS