UniProt Accession

 LTOR1_MOUSE; Q9CQ22; Q9CYS0 

Genbank Protein ID

 AK009320; AK013389; AK019947; AK144476; BC020142; BC092062; BC096412; BC115458; BC115459; BC126973 

Genbank Nucleotide ID

 BAB26214.1; BAB28825.1; BAB31928.1; BAE25909.1; AAH20142.1; AAH92062.1; AAH96412.1; AAI26974.1 

Protein Name

 Ragulator complex protein LAMTOR1 

Protein Synonyms/Alias

 Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18 

Gene Name

 Lamtor1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
20	DQDREERKLLLDPSS	ubiquitination	[1]
31	DPSSTPTKALNGAEP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. 

Sequence Annotation

 REGION 121 161 Interaction with LAMTOR2 and LAMTOR3 (By
 MOD_RES 27 27 Phosphoserine (By similarity).
 MOD_RES 28 28 Phosphothreonine.
 MOD_RES 63 63 Phosphoserine.
 LIPID 2 2 N-myristoyl glycine (Potential).  

Keyword

 Cell membrane; Complete proteome; Endosome; Lipoprotein; Lysosome; Membrane; Myristate; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 161 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0071986; C:Ragulator complex; ISS:UniProtKB.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Compara.
 GO:0016049; P:cell growth; ISS:UniProtKB.
 GO:0034613; P:cellular protein localization; IMP:UniProtKB.
 GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
 GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.
 GO:0032439; P:endosome localization; IMP:UniProtKB.
 GO:0007032; P:endosome organization; IMP:UniProtKB.
 GO:0032418; P:lysosome localization; IMP:UniProtKB.
 GO:0007040; P:lysosome organization; IMP:UniProtKB.
 GO:0043410; P:positive regulation of MAPK cascade; IMP:UniProtKB.
 GO:0032008; P:positive regulation of TOR signaling cascade; ISS:UniProtKB.
 GO:0010874; P:regulation of cholesterol efflux; ISS:UniProtKB.
 GO:0010872; P:regulation of cholesterol esterification; ISS:UniProtKB.
 GO:0060620; P:regulation of cholesterol import; ISS:UniProtKB.
 GO:0001919; P:regulation of receptor recycling; IMP:UniProtKB. 

Interpro

 IPR026310; LAMTOR1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS