CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044459
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein kinase tousled-like 2 
Protein Synonyms/Alias
  
Gene Name
 TLK2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
124LMSVMLAKPRLDTEQubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 593 AA 
Protein Sequence
MMEELHSLDP RRQELLEARF TGVGVSKGPL NSESSNQSLC SVGSLSDKEV ETPEKKQNDQ 60
RNRKRKAEPY ETSQGKGTPR GHKISDYFER RVEQPLYGLD GSAAKEATEE QSALPTLMSV 120
MLAKPRLDTE QLAQRGAGLC FTFVSSDLTI EKISALENSK NSDLEKKEGR IDDLLRANCD 180
LRRQIDEQQK MLEKYKERLN RCVTMSKKLL IEKSKQEKMA CRDKSMQDRL RLGHFTTVRH 240
GASFTEQWTD GYAFQNLIKQ QERINSQREE IERQRKMLAK RKPPAMGQAP PATNEQKQRK 300
SKTNGAENET LTLAEYHEQE EIFKLRLGHL KKEEAEIQAE LERLERVRNL HIRELKRIHN 360
EDNSQFKDHP TLNDRYLLLH LLGRGGFSEV YKAFDLTEQR YVAVKIHQLN KNWRDEKKEN 420
YHKHACREYR IHKELDHPRI VKLYDYFSLD TDSFCTVLEY CEGNDLDFYL KQHKLMSEKE 480
ARSIIMQIVN ALKYLNEIKP PIIHYDLKPG NILLVNGTAC GEIKITDFGL SKIMDDDSYN 540
SVDGMELTSQ GAGTYWYLPP ECFVVGKEPP KISNKVDVWS VGVIFYQCLY GRK 593 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS.
 IPR027086; TLK. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS