| Tag | Content |
|---|
| CPLM ID | CPLM-000644 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Structural maintenance of chromosomes protein 3 |
Protein Synonyms/Alias | Cohesin complex Psm3 subunit |
Gene Name | psm3 |
Gene Synonyms/Alias | smc3; SPAC10F6.09c |
Created Date | July 27, 2013 |
Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
NCBI Taxa ID | 284812 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 105 | LRRTIGLKKDEYSLD | acetylation | [1] | | 106 | RRTIGLKKDEYSLDK | acetylation | [1] |
|
Reference | [1] Psm3 acetylation on conserved lysine residues is dispensable for viability in fission yeast but contributes to Eso1-mediated sister chromatid cohesion by antagonizing Wpl1. Feytout A, Vaur S, Genier S, Vazquez S, Javerzat JP. Mol Cell Biol. 2011 Apr;31(8):1771-86. [ PMID: 21300781] |
Functional Description | Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. |
Sequence Annotation | NP_BIND 32 39 ATP (Potential).
REGION 498 667 Flexible hinge.
MOD_RES 105 105 N6-acetyllysine (By similarity).
MOD_RES 106 106 N6-acetyllysine (By similarity). |
Keyword | Acetylation; ATP-binding; Cell cycle; Cell division; Chromosome; Coiled coil; Complete proteome; Mitosis; Nucleotide-binding; Nucleus; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1194 AA |
Protein Sequence | MYITKIVIQG FKSYKDYTVI EPLSPHHNVI VGRNGSGKSN FFAAIRFVLS DAYTHLSREE 60
RQALLHEGPG ATVMSAYVEV TFANADNRFP TGKSEVVLRR TIGLKKDEYS LDKKTVSKTE 120
VINLLESAGF SRSNPYYIVP QGRVTSLTNA KDSERLELLK EVAGTQIYEN RRAESNKIMD 180
ETIQKSEKID ELLQYIEERL RELEEEKNDL AVYHKKDNER RCLEYAIYSR EHDEINSVLD 240
ALEQDRIAAL ERNDDDSGAF IQREERIERI KAEITELNHS LELLRVEKQQ NDEDYTNIMK 300
SKVALELQSS QLSRQIEFSK KDESSKLNIL SELESKISEK ENELSEILPK YNAIVSEADD 360
LNKRIMLLKN QKQSLLDKQS RTSQFTTKKE RDEWIRNQLL QINRNINSTK ENSDYLKTEY 420
DEMENELKAK LSRKKEIEIS LESQGDRMSQ LLANITSINE RKENLTDKRK SLWREEAKLK 480
SSIENVKDDL SRSEKALGTT MDRNTSNGIR AVKDIAERLK LEGYYGPLCE LFKVDNRFKV 540
AVEATAGNSL FHIVVDNDET ATQILDVIYK ENAGRVTFMP LNKLRPKAVT YPDASDALPL 600
IQYLEFDPKF DAAIKQVFSK TIVCPSIETA SQYARSHQLN GITLSGDRSD KKGALTAGYR 660
DYRNSRLDAI KNVKTYQIKF SDLQESLEKC RSEIESFDQK ITACLDDLQK AQLSLKQFER 720
DHIPLKDELV TITGETTDLQ ESMHHKSRML ELVVLELHTL EQQANDLKSE LSSEMDELDP 780
KDVEALKSLS GQIENLSHEF DAIIKERAHI EARKTALEYE LNTNLYLRRN PLKAEIGSDN 840
RIDESELNSV KRSLLKYENK LQIIKSSSSG LEEQMQRINS EISDKRNELE SLEELQHEVA 900
TRIEQDAKIN ERNAAKRSLL LARKKECNEK IKSLGVLPEE AFIKYVSTSS NAIVKKLHKI 960
NEALKDYGSV NKKAYEQFNN FTKQRDSLLA RREELRRSQE SISELTTVLD QRKDEAIERT 1020
FKQVAKSFSE IFVKLVPAGR GELVMNRRSE LSQSIEQDIS MDIDTPSQKS SIDNYTGISI 1080
RVSFNSKDDE QLNINQLSGG QKSLCALTLI FAIQRCDPAP FNILDECDAN LDAQYRSAIA 1140
AMVKEMSKTS QFICTTFRPE MVKVADNFYG VMFNHKVSTV ESISKEEAMA FVEG 1194 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |