CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022806
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Eukaryotic translation initiation factor 3 subunit H 
Protein Synonyms/Alias
 eIF3h; Eukaryotic translation initiation factor 3 subunit 3 
Gene Name
 eIF-3p40 
Gene Synonyms/Alias
 eif3-S3; Dmel_CG9124 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
146SRGFLCLKAYRLTPQacetylation[1]
243QEAVRYNKYQQVVFKacetylation[1]
250KYQQVVFKQDTEKHRacetylation[1]
261EKHRALAKLAAENAVacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome (By similarity). 
Sequence Annotation
 DOMAIN 17 127 MPN.  
Keyword
 Complete proteome; Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 338 AA 
Protein Sequence
MANRANRHAA RTEDSDNTIN YVQCDGLAVM KMVKHCHEES SNMDLAQGAL LGLVVDKCLE 60
ITNCFPFPKS GDETMDEEMY QLTVMRRLRR VNVDHLHVGW YQSSDVGNSL SMALLESQYH 120
YQTSIEESVV VVYDTQKSSR GFLCLKAYRL TPQAIQMYKD GDFTPEAFRT LKVGYENLFA 180
EIPIVIKNSP LTNIMMSELN ELLPEDKGHN FLDLGTATVL ENQMRSLIER VDELYQEAVR 240
YNKYQQVVFK QDTEKHRALA KLAAENAVRT SKGEPTVPEE EVIKQFRPMT APNRLTATIT 300
SGQINTHAQH IAQFCSQSLA KLFITESLQI AKEAKETK 338 
Gene Ontology
 GO:0005829; C:cytosol; ISS:FlyBase.
 GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:HAMAP.
 GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:HAMAP.
 GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:FlyBase.
 GO:0003743; F:translation initiation factor activity; ISS:FlyBase.
 GO:0001731; P:formation of translation preinitiation complex; IEA:HAMAP.
 GO:0022008; P:neurogenesis; IMP:FlyBase.
 GO:0045747; P:positive regulation of Notch signaling pathway; IMP:FlyBase.
 GO:0006446; P:regulation of translational initiation; IEA:HAMAP. 
Interpro
 IPR027524; eIF3h.
 IPR000555; JAB1_Mov34_MPN_PAD1. 
Pfam
 PF01398; JAB 
SMART
 SM00232; JAB_MPN 
PROSITE
  
PRINTS