CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020937
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cysteine sulfinic acid decarboxylase 
Protein Synonyms/Alias
 Cysteine-sulfinate decarboxylase; Sulfinoalanine decarboxylase 
Gene Name
 Csad 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
42KGTSASEKVCEWKEPubiquitination[1]
47SEKVCEWKEPEELKQacetylation[2]
47SEKVCEWKEPEELKQubiquitination[1]
53WKEPEELKQLLDLELubiquitination[1]
83TVIHYSVKTGHPRFFubiquitination[1]
172FQRYPDCKQRGLRALubiquitination[1]
188PLALFTSKECHYSITubiquitination[1]
196ECHYSITKGAAFLGLubiquitination[1]
305SVAWNPHKLLAAGLQacetylation[2]
326RDTSNLLKRCHGSQAubiquitination[1]
352VALDTGDKVVQCGRRubiquitination[1]
442SQVAPVLKERMVKKGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
 MOD_RES 305 305 N6-(pyridoxal phosphate)lysine (By  
Keyword
 Complete proteome; Decarboxylase; Lyase; Pyridoxal phosphate; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 493 AA 
Protein Sequence
MADSKPLRTL DGDPVAVEAL LQDVFGIVVD EAILKGTSAS EKVCEWKEPE ELKQLLDLEL 60
QSQGESREQI LERCRTVIHY SVKTGHPRFF NQLFSGLDPH ALAGRIITES LNTSQYTYEI 120
APVFVLMEEE VLKKLRALVG WNSGDGVFCP GGSISNMYAM NLARFQRYPD CKQRGLRALP 180
PLALFTSKEC HYSITKGAAF LGLGTDSVRV VKADERGRMI PEDLERQIIL AEAEGSVPFL 240
VSATSGTTVL GAFDPLDAIA DVCQRHGLWF HVDAAWGGSV LLSRTHRHLL DGIQRADSVA 300
WNPHKLLAAG LQCSALLLRD TSNLLKRCHG SQASYLFQQD KFYDVALDTG DKVVQCGRRV 360
DCLKLWLMWK AQGGQGLERR IDQAFALTRY LVEEIKKREG FELVMEPEFV NVCFWFVPPS 420
LRGKKESPDY SQRLSQVAPV LKERMVKKGT MMIGYQPHGT RANFFRMVVA NPILAQADID 480
FLLGELELLG QDL 493 
Gene Ontology
 GO:0016831; F:carboxy-lyase activity; TAS:MGI.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0004782; F:sulfinoalanine decarboxylase activity; IEA:EC.
 GO:0019452; P:L-cysteine catabolic process to taurine; TAS:MGI.
 GO:0042412; P:taurine biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR002129; PyrdxlP-dep_de-COase.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR021115; Pyridoxal-P_BS. 
Pfam
 PF00282; Pyridoxal_deC 
SMART
  
PROSITE
 PS00392; DDC_GAD_HDC_YDC 
PRINTS