UniProt Accession

 FUS_MOUSE; P56959 

Genbank Protein ID

 AF224264 

Genbank Nucleotide ID

 AAF70602.1 

Protein Name

 RNA-binding protein FUS 

Protein Synonyms/Alias

 Protein pigpen 

Gene Name

 Fus 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
309	GIIKTNKKTGQPMIN	ubiquitination	[1]
327	DRETGKLKGEATVSF	ubiquitination	[1]
341	FDDPPSAKAAIDWFD	ubiquitination	[1]
350	AIDWFDGKEFSGNPI	ubiquitination	[1]
358	EFSGNPIKVSFATRR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity (By similarity). 

Sequence Annotation

 DOMAIN 278 364 RRM.
 ZN_FING 415 446 RanBP2-type.
 MOD_RES 217 217 Omega-N-methylated arginine (By
 MOD_RES 219 219 Omega-N-methylated arginine (By
 MOD_RES 235 235 Asymmetric dimethylarginine (By
 MOD_RES 237 237 Asymmetric dimethylarginine (By
 MOD_RES 241 241 Asymmetric dimethylarginine (By
 MOD_RES 244 244 Asymmetric dimethylarginine (By
 MOD_RES 252 252 Asymmetric dimethylarginine (By
 MOD_RES 270 270 Phosphoserine (By similarity).
 MOD_RES 279 279 Phosphothreonine (By similarity).
 MOD_RES 370 370 Asymmetric dimethylarginine (By
 MOD_RES 376 376 Asymmetric dimethylarginine (By
 MOD_RES 379 379 Asymmetric dimethylarginine (By
 MOD_RES 381 381 Asymmetric dimethylarginine (By
 MOD_RES 387 387 Asymmetric dimethylarginine (By
 MOD_RES 400 400 Asymmetric dimethylarginine (By
 MOD_RES 466 466 Asymmetric dimethylarginine (By
 MOD_RES 468 468 Asymmetric dimethylarginine (By
 MOD_RES 473 473 Asymmetric dimethylarginine (By
 MOD_RES 477 477 Asymmetric dimethylarginine (By
 MOD_RES 479 479 Asymmetric dimethylarginine (By
 MOD_RES 483 483 Asymmetric dimethylarginine (By
 MOD_RES 487 487 Asymmetric dimethylarginine (By
 MOD_RES 490 490 Asymmetric dimethylarginine (By
 MOD_RES 495 495 Asymmetric dimethylarginine (By  

Keyword

 Complete proteome; DNA-binding; Metal-binding; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 518 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR001876; Znf_RanBP2. 

Pfam

 PF00076; RRM_1
 PF00641; zf-RanBP 

SMART

 SM00360; RRM
 SM00547; ZnF_RBZ 

PROSITE

 PS50102; RRM
 PS01358; ZF_RANBP2_1
 PS50199; ZF_RANBP2_2 

PRINTS