CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013032
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vesicular glutamate transporter 1 
Protein Synonyms/Alias
 VGluT1; Brain-specific Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7 
Gene Name
 Slc17a7 
Gene Synonyms/Alias
 Bnpi; Vglut1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
272SISEEERKYIEDAIGubiquitination[1]
283DAIGESAKLMNPVTKubiquitination[1]
290KLMNPVTKFNTPWRRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. 
Sequence Annotation
  
Keyword
 Cell junction; Complete proteome; Cytoplasmic vesicle; Ion transport; Membrane; Neurotransmitter transport; Reference proteome; Sensory transduction; Sodium; Sodium transport; Symport; Synapse; Synaptosome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 560 AA 
Protein Sequence
MEFRQEEFRK LAGRALGRLH RLLEKRQEGA ETLELSADGR PVTTHTRDPP VVDCTCFGLP 60
RRYIIAIMSG LGFCISFGIR CNLGVAIVSM VNNSTTHRGG HVVVQKAQFN WDPETVGLIH 120
GSFFWGYIVT QIPGGFICQK FAANRVFGFA IVATSTLNML IPSAARVHYG CVIFVRILQG 180
LVEGVTYPAC HGIWSKWAPP LERSRLATTA FCGSYAGAVV AMPLAGVLVQ YSGWSSVFYV 240
YGSFGIFWYL FWLLVSYESP ALHPSISEEE RKYIEDAIGE SAKLMNPVTK FNTPWRRFFT 300
SMPVYAIIVA NFCRSWTFYL LLISQPAYFE EVFGFEISKV GLVSALPHLV MTIIVPIGGQ 360
IADFLRSRHI MSTTNVRKLM NCGGFGMEAT LLLVVGYSHS KGVAISFLVL AVGFSGFAIS 420
GFNVNHLDIA PRYASILMGI SNGVGTLSGM VCPIIVGAMT KHKTREEWQY VFLIASLVHY 480
GGVIFYGVFA SGEKQPWAEP EEMSEEKCGF VGHDQLAGSD ESEMEDEAEP PGAPPAPPPS 540
YGATHSTVQP PRPPPPVRDY 560 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0060076; C:excitatory synapse; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
 GO:0048786; C:presynaptic active zone; IDA:BHF-UCL.
 GO:0030672; C:synaptic vesicle membrane; IDA:MGI.
 GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:Compara.
 GO:0015321; F:sodium-dependent phosphate transmembrane transporter activity; IEA:Compara.
 GO:0015319; F:sodium:inorganic phosphate symporter activity; IEA:Compara.
 GO:0051938; P:L-glutamate import; IDA:MGI.
 GO:0007616; P:long-term memory; IMP:MGI.
 GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IMP:MGI.
 GO:0042137; P:sequestering of neurotransmitter; IMP:MGI.
 GO:0035249; P:synaptic transmission, glutamatergic; IMP:MGI. 
Interpro
 IPR011701; MFS.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt. 
Pfam
 PF07690; MFS_1 
SMART
  
PROSITE
 PS50850; MFS 
PRINTS