| Tag | Content |
|---|
| CPLM ID | CPLM-007884 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mitochondrial division protein 1 |
Protein Synonyms/Alias | Mitochondria fission 2 protein |
Gene Name | MDV1 |
Gene Synonyms/Alias | FIS2; GAG3; NET2; YJL112W; J0802 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 126 | LKSDADGKLLTEGGE | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Involved in mitochondrial fission. Has a partially redundant function to CAF4 in acting as an adapter protein, binding to FIS1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase DNM1 to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division. |
Sequence Annotation | REPEAT 396 436 WD 1.
REPEAT 439 478 WD 2.
REPEAT 500 539 WD 3.
REPEAT 561 603 WD 4.
REPEAT 604 642 WD 5.
REPEAT 644 681 WD 6.
REPEAT 685 714 WD 7.
MOD_RES 376 376 Phosphoserine. |
Keyword | 3D-structure; Coiled coil; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Reference proteome; Repeat; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 714 AA |
Protein Sequence | MSVNDQITHI GKTLSTTASA FLNYQKSNSN TQDVLTNNGP YKNLLSNTVN NASSTSYFYK 60
RTEHGRFVKN ASNTFEDIYS KTRRGDVFRN KFTDNKTCFR MLTYISDDLL NEIPTKEGLK 120
SDADGKLLTE GGENENLRKN ASKKETSLFQ GFKSYLPIAE LAIENTERLN YDTNGTSGTV 180
GAKDVMSKTN ERDEIHTELP NFQDSFLIPP GVETKKISSS YSPSALKSFS QTLVNSLEFL 240
NIQKNSTLSE IRDIEVEVEN LRQKKEKLLG KIANIEQNQL LLEDNLKQID DRLDFLEEYG 300
LEVIEANSDE NAEDDGMSER KALKNDAIRN EGVTTESISS EASNLPPRRR QQLRDDNSLN 360
RLGAFYSKSK KRHRKSFPTF QQLYEPGTKI GSIMSTHDDF LTCLDFDAPF GTLCTAGYLD 420
HTVKIWDLSK QNKIGELAGH LATINCMQIN RDYGTLVTGG RDAALKLWNL NLAQQLYQET 480
QNLTSPTNHI DSPCVHTFEA HTDEVTALSL DPSFLVSGSQ DRTIRQWDLR SGKCLQTIDL 540
SFANVLTTST NVDLSKSTLL TQRNERPSIG ALQSFDAALA TGTKDGVVRL WDLRSGKVIR 600
TLKGHTDAIT SLKFDSACLV TGSYDRTVRI WDLRTGLLNK FHAYSAPVLS LDLFQENAAV 660
VVADEPSVQI YDSEKDESWS CVEQGNETSV STVKYKENYM VEGRENGDVN IWAV 714 |
Gene Ontology | |
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PROSITE | |
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