CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011102
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Trafficking protein particle complex II-specific subunit 130 
Protein Synonyms/Alias
 TRAPP II-specific subunit 130; Transport protein particle 130 kDa subunit 
Gene Name
 TRS130 
Gene Synonyms/Alias
 YMR218C; YM8261.12C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
66EGRGEADKSNDEQPFubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Specific subunit of the TRAPP II complex, a highly conserved vesicle tethering complex that functions in the late Golgi as a guanine nucleotide exchange factor (GEF) for the Golgi YPT1 GTPase. TRS130 plays a role in the YPT GEF activity of TRAPP II in concert with the two other TRAPP II-specific subunits TRS65 and TRS120. Required for both the cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy through its role in ATG8 and ATG9 trafficking. 
Sequence Annotation
  
Keyword
 Autophagy; Complete proteome; Golgi apparatus; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1102 AA 
Protein Sequence
MDKEIYCGSV PVSYFDPFDL FESLRPEFQQ ILPLDNIHWK AFDGTVRTVN RLPIELIPEG 60
RGEADKSNDE QPFIRFLIVN CISIDQYRAK VRPLVRQWLP NLESVSSSTG EKMIYKPIIL 120
LYANSEVVDS NLFKSVSLME KFGKDFPHVQ TLEVRSVYRS PKERQEFWNQ FSQKIKASVL 180
SIFQKRLTHL QHSLANLQKG NNFEEQLLTR EKLYELYVVF NILEDASLEL QKIKKEILRR 240
NMNMPDGKLQ VPFESSSKSD ESLGSIIIEG TLDKFQLHKY FFIRRLRLLK LEDQTLTAFV 300
GAFQLIKNFI ESISIEYRKS VRLLEFKHYF ITSMLSYFEF ENVSNPLLCE IKAELLMLKR 360
DNWVQGVMAT SGYRLMDKNY PNSDVKYKFD LLKETFVDET VFQENFLTLT KEILSLFNKC 420
EGKRQRIVDI LSIEIGLLYY QGKKYEEAVS LFLSCYEYYT QTNWNSIGLK ILQVFIDSLS 480
HCPKLDVLQI DGESVSASAV LTNAFLNILK LCKDNDSKEI WWKKFMDLQM KNNIHLMYPL 540
DGLFEVTLNS KVHLARANVS AIEVNLKSYG FPEDISTKTM RLSLKNMGGD VIVFGASDFL 600
LKKGENKLIL ECRDIMYGEF SLLSFEIIVE GITFVKEFPE NQDEFIVVPE IYCKESTKVL 660
VKQAHNLNLG EYALELKSVQ SDALESLQVE VEVQKNIGNM KNLPVSFSMD EIQARKRYNT 720
PFENVRLEYY LLDQITAFDL IIKTSFTKKN DQGTFGETKK VRIQCYLQLS VSVEDIFKKD 780
IFFFKFLLNS SVREEPVILY SSELSAPDTR NDYNIRGDYI ATTPALITFD GNESFINCYE 840
ITANNNFDSK DIFNLKVRYN TLKEQLDCFI TDAVLIEGDV EWFILFEKWK TFWELEILKK 900
LKYDYDAFKE NRIIRLLKTS IDLNKTKSKI RNLCIEKAVL DKILICLNKV SRGIAVCNTD 960
MDEYVRNLVP KQLTVPVQLP GFEQFFHVQF EQMETSHDAL HDTIATIGNS LSYTVIVENL 1020
SGQWGQDVID DGGYIFEILS SNEWLIHGQK RCAIKEKRKE FEVHLIPLKK GYLNFPRVEI 1080
TNINGKSCRV DHSNAFESIL IF 1102 
Gene Ontology
 GO:0005769; C:early endosome; IDA:SGD.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005802; C:trans-Golgi network; IDA:SGD.
 GO:0030008; C:TRAPP complex; IDA:SGD.
 GO:0032258; P:CVT pathway; IMP:SGD.
 GO:0034498; P:early endosome to Golgi transport; IMP:SGD.
 GO:0006891; P:intra-Golgi vesicle-mediated transport; IMP:SGD.
 GO:0016236; P:macroautophagy; IMP:SGD.
 GO:0032313; P:regulation of Rab GTPase activity; IMP:SGD. 
Interpro
 IPR022233; TRAPP_II_complex_TRAPPC10. 
Pfam
 PF12584; TRAPPC10 
SMART
  
PROSITE
  
PRINTS