CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001156
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ectonucleoside triphosphate diphosphohydrolase 6 
Protein Synonyms/Alias
 NTPDase 6; CD39 antigen-like 2 
Gene Name
 ENTPD6 
Gene Synonyms/Alias
 CD39L2; IL6ST2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
139HETFKALKPGLSAYAubiquitination[1, 2]
164RELLDVAKQDIPFDFubiquitination[1, 2]
173DIPFDFWKATPLVLKubiquitination[2]
192LRLLPGEKAQKLLQKubiquitination[2]
316GVEGQPAKDGKELVSubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5'-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP (By similarity). 
Sequence Annotation
 ACT_SITE 224 224 Proton acceptor (By similarity).
 CARBOHYD 220 220 N-linked (GlcNAc...) (Potential).
 CARBOHYD 284 284 N-linked (GlcNAc...) (Potential).
 DISULFID 325 356 In soluble form.
 DISULFID 416 430 In soluble form.  
Keyword
 Alternative splicing; Calcium; Complete proteome; Disulfide bond; Glycoprotein; Golgi apparatus; Hydrolase; Magnesium; Membrane; Polymorphism; Reference proteome; Secreted; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 484 AA 
Protein Sequence
MKKGIRYETS RKTSYIFQQP QHGPWQTRMR KISNHGSLRV AKVAYPLGLC VGVFIYVAYI 60
KWHRATATQA FFSITRAAPG ARWGQQAHSP LGTAADGHEV FYGIMFDAGS TGTRVHVFQF 120
TRPPRETPTL THETFKALKP GLSAYADDVE KSAQGIRELL DVAKQDIPFD FWKATPLVLK 180
ATAGLRLLPG EKAQKLLQKV KKVFKASPFL VGDDCVSIMN GTDEGVSAWI TINFLTGSLK 240
TPGGSSVGML DLGGGSTQIA FLPRVEGTLQ ASPPGYLTAL RMFNRTYKLY SYSYLGLGLM 300
SARLAILGGV EGQPAKDGKE LVSPCLSPSF KGEWEHAEVT YRVSGQKAAA SLHELCAARV 360
SEVLQNRVHR TEEVKHVDFY AFSYYYDLAA GVGLIDAEKG GSLVVGDFEI AAKYVCRTLE 420
TQPQSSPFSC MDLTYVSLLL QEFGFPRSKV LKLTRKIDNV ETSWALGAIF HYIDSLNRQK 480
SPAS 484 
Gene Ontology
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0008894; F:guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity; IEA:Compara.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:Compara.
 GO:0045134; F:uridine-diphosphatase activity; IEA:EC.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0032026; P:response to magnesium ion; IEA:Compara. 
Interpro
 IPR000407; GDA1_CD39_NTPase. 
Pfam
 PF01150; GDA1_CD39 
SMART
  
PROSITE
 PS01238; GDA1_CD39_NTPASE 
PRINTS