CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014318
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Double-strand break repair protein MRE11A 
Protein Synonyms/Alias
 MmMRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A 
Gene Name
 Mre11a 
Gene Synonyms/Alias
 Mre11 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
443QYFQTAEKNVQLSLLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity). 
Sequence Annotation
 ACT_SITE 129 129 Proton donor (By similarity).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 648 648 Phosphoserine (By similarity).
 MOD_RES 686 686 Phosphoserine (By similarity).
 MOD_RES 699 699 Phosphoserine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Complete proteome; DNA damage; DNA repair; Endonuclease; Exonuclease; Hydrolase; Manganese; Meiosis; Nuclease; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 706 AA 
Protein Sequence
MSPTDPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN EVDFILLGGD 60
LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEVISDQSVN FGFSKFPWVN YQDGNLNISI 120
PVFSIHGNHD DPTGADALCA LDVLSCAGFV NHFGRSMSVE KVDISPVLLQ KGSTKLALYG 180
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGNTNFIP EQFLDDFIDL 240
VIWGHEHECK IGPIKNEQQL FYVSQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMQKLP 300
LRTVRRFFIE DVVLANHPNL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE RLGNPQQPGK 360
PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR HREQKGKTGE EINFGMLITK 420
PASEGATLRV EDLVKQYFQT AEKNVQLSLL TERGMGEAVQ EFVDKEEKDA IEELVKYQLE 480
KTQRFLKERH IDALEDKIDE EVRRFRESRQ RNTNEEDDEV REAMSRARAL RSQSETSTSA 540
FSAEDLSFDT SEQTANDSDD SLSAVPSRGR GRGRGRRGAR GQSSAPRGGS QRGRDTGLEI 600
TTRGRSSKAT SSTSRNMSII DAFRSTRQQP SRNVAPKNYS ETIEVDDSDE DDIFPTNSRA 660
DQRWSGTTSS KRMSQSQTAK GVDFESDEDD DDDPFMSSSC PRRNRR 706 
Gene Ontology
 GO:0000781; C:chromosome, telomeric region; IEA:Compara.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0004003; F:ATP-dependent DNA helicase activity; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
 GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
 GO:0030145; F:manganese ion binding; IEA:InterPro.
 GO:0008283; P:cell proliferation; IMP:MGI.
 GO:0006302; P:double-strand break repair; IMP:MGI.
 GO:0031573; P:intra-S DNA damage checkpoint; IMP:MGI.
 GO:0007095; P:mitotic G2 DNA damage checkpoint; IMP:MGI.
 GO:0032876; P:negative regulation of DNA endoreduplication; IEA:Compara.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0033674; P:positive regulation of kinase activity; IEA:Compara.
 GO:0031954; P:positive regulation of protein autophosphorylation; IEA:Compara.
 GO:0007062; P:sister chromatid cohesion; IEA:Compara.
 GO:0007129; P:synapsis; IMP:MGI. 
Interpro
 IPR003701; DNA_repair_Mre11.
 IPR004843; Metallo_PEstase_dom.
 IPR007281; Mre11_DNA-bd. 
Pfam
 PF00149; Metallophos
 PF04152; Mre11_DNA_bind 
SMART
  
PROSITE
  
PRINTS