UniProt Accession

 B4DH70_HUMAN; B4DH70 

Genbank Protein ID

 AC011387; AC011410; AC113342; AK294956 

Genbank Nucleotide ID

 BAG58031.1 

Protein Name

 F-box/WD repeat-containing protein 11 

Protein Synonyms/Alias

 cDNA FLJ54601, highly similar to F-box/WD repeat protein 11 

Gene Name

 FBXW11 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
147	VRTDPLWKGLSERRG	methylation	[1]
147	VRTDPLWKGLSERRG	ubiquitination	[2, 3]
434	GAYDGKIKVWDLQAA	ubiquitination	[3]

Reference

 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 510 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR021977; Beta-TrCP_D.
 IPR001810; F-box_dom_cyclin-like.
 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF12125; Beta-TrCP_D
 PF00400; WD40 

SMART

 SM01028; Beta-TrCP_D
 SM00256; FBOX
 SM00320; WD40 

PROSITE

 PS50181; FBOX
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.