UniProt Accession

 SPEE_YEAST; Q12074; D6W473 

Genbank Protein ID

 U27519; Z71255; Z49219; U51033; BK006949 

Genbank Nucleotide ID

 AAC17191.1; CAA94977.1; CAA89186.1; AAB68120.1; DAA11489.1 

Protein Name

 Spermidine synthase 

Protein Synonyms/Alias

 SPDSY; Putrescine aminopropyltransferase 

Gene Name

 SPE3 

Gene Synonyms/Alias

 YPR069C; YP9499.24C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
31	PGQAMTLKVEKVLHH	ubiquitination	[1]
42	VLHHEKSKYQDVLIF	acetylation	[2]
129	EAVIRLSKEYLPEMA	acetylation	[2]
265	LREISDEKEAELYRY	acetylation	[2]
265	LREISDEKEAELYRY	ubiquitination	[1]
276	LYRYYNKKIHEASFV	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

  

Sequence Annotation

 REGION 150 151 S-adenosylmethioninamine binding (By
 REGION 168 171 Putrescine binding (By similarity).
 ACT_SITE 168 168 Proton acceptor (By similarity).
 BINDING 44 44 S-adenosylmethioninamine (By similarity).
 BINDING 74 74 Putrescine (By similarity).
 BINDING 75 75 S-adenosylmethioninamine (By similarity).
 BINDING 99 99 S-adenosylmethioninamine (By similarity).
 BINDING 119 119 S-adenosylmethioninamine (By similarity).
 BINDING 168 168 S-adenosylmethioninamine (By similarity).
 BINDING 236 236 Putrescine (By similarity).  

Keyword

 Complete proteome; Reference proteome; Spermidine biosynthesis; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 293 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004766; F:spermidine synthase activity; IMP:SGD.
 GO:0015940; P:pantothenate biosynthetic process; IMP:SGD.
 GO:0008295; P:spermidine biosynthetic process; IMP:SGD. 

Interpro

 IPR001045; Spermidine/spermine_synthase. 

Pfam

 PF01564; Spermine_synth 

SMART

  

PROSITE

 PS01330; SPERMIDINE_SYNTHASE_1
 PS51006; SPERMIDINE_SYNTHASE_2 

PRINTS