UniProt Accession

 IGBP1_HUMAN; P78318; Q8TAB2 

Genbank Protein ID

 Y08915; BT006736; AL158141; AL139111; BC004137 

Genbank Nucleotide ID

 CAA70119.1; AAP35382.1; CAD13488.2; CAD13488.2; AAH04137.1 

Protein Name

 Immunoglobulin-binding protein 1 

Protein Synonyms/Alias

 B-cell signal transduction molecule alpha 4; Protein alpha-4; CD79a-binding protein 1; Protein phosphatase 2/4/6 regulatory subunit; Renal carcinoma antigen NY-REN-16 

Gene Name

 IGBP1 

Gene Synonyms/Alias

 IBP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
44	IVQEKVFKGLDLLEK	ubiquitination	[1, 2, 3, 4, 5]
91	FQGALTMKQVNPSKR	ubiquitination	[3, 5]
176	EHRLSAMKSAVESGQ	ubiquitination	[6]
241	RQERPPVKPFILTRN	acetylation	[5, 7, 8]
241	RQERPPVKPFILTRN	ubiquitination	[1, 2, 3, 4]
253	TRNMAQAKVFGAGYP	ubiquitination	[1, 4]
287	LPDQGIAKAAPEEFR	ubiquitination	[3, 6]
295	AAPEEFRKAAQQQEE	ubiquitination	[6]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [7] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [8] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits. 

Sequence Annotation

 REPEAT 46 60 UIM.
 REGION 98 202 Interaction with PPP2CA.
 REGION 225 290 Interaction with MID1.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 241 241 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; B-cell activation; Chaperone; Complete proteome; Cytoplasm; Mental retardation; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 339 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; NAS:UniProtKB.
 GO:0008601; F:protein phosphatase type 2A regulator activity; IDA:UniProtKB.
 GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
 GO:0035308; P:negative regulation of protein dephosphorylation; IEA:Compara.
 GO:0032873; P:negative regulation of stress-activated MAPK cascade; IMP:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
 GO:0035306; P:positive regulation of dephosphorylation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0060632; P:regulation of microtubule-based movement; IMP:UniProtKB.
 GO:0070555; P:response to interleukin-1; IMP:UniProtKB.
 GO:0034612; P:response to tumor necrosis factor; IMP:UniProtKB.
 GO:0007165; P:signal transduction; NAS:UniProtKB. 

Interpro

 IPR007304; TAP42-like. 

Pfam

 PF04177; TAP42 

SMART

  

PROSITE

 PS50330; UIM 

PRINTS