UniProt Accession

 TIM21_HUMAN; Q9BVV7; Q9P010 

Genbank Protein ID

 AF161503; BC000892 

Genbank Nucleotide ID

 AAF29118.1; AAH00892.1 

Protein Name

 Mitochondrial import inner membrane translocase subunit Tim21 

Protein Synonyms/Alias

 TIM21-like protein, mitochondrial 

Gene Name

 TIMM21 

Gene Synonyms/Alias

 C18orf55; HSPC154; TIM21 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
32	LPYIVLNKACLKTEP	ubiquitination	[1]
185	VRFTEYVKDGLKHTC	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex. TIM21 probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. 

Sequence Annotation

  

Keyword

 Complete proteome; Membrane; Mitochondrion; Polymorphism; Protein transport; Reference proteome; Transit peptide; Translocation; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 248 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005744; C:mitochondrial inner membrane presequence translocase complex; IDA:UniProtKB.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
 GO:0033617; P:mitochondrial respiratory chain complex IV assembly; IMP:UniProtKB.
 GO:0030150; P:protein import into mitochondrial matrix; IMP:UniProtKB. 

Interpro

 IPR013261; Tim21. 

Pfam

 PF08294; TIM21 

SMART

  

PROSITE

  

PRINTS