CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026936
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acetyl-coenzyme A synthetase 2-like, mitochondrial 
Protein Synonyms/Alias
 cDNA FLJ43068 fis, clone BRTHA3008778, moderately similar to Acetyl-coenzyme A synthetase (EC 6.2.1.1) 
Gene Name
 ACSS1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
440RFVDAYFKAYPGYYFubiquitination[1]
550PDEILVVKRLPKTRSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 606 AA 
Protein Sequence
MLKTFLFLEK YFPCIKYSSA CFPGTGLDVY DIKFAVLLHP QTALHFGPPP SLMAFSSLCC 60
RELLETTCRL ANTLKRHGVH RGDRVAIYMP VSPLAVAAML ACARIGAVHT VIFAGFSAES 120
LAGRINDAKC KVVITFNQGL RGGRVVELKK IVDEAVKHCP TVQHVLVAHR TDNKVHMGDL 180
DVPLEQEMAK EDPVCAPESM GSEDMLFMLY TSGSTGMPKG IVHTQAGYLL YAALTHKLVF 240
DHQPGDIFGC VADIGWITGH SYVVYGPLCN GATSVLFEST PVYPNAGRYW ETVERLKINQ 300
FYGAPTAVRL LLKYGDAWVK KYDRSSLRTL GSVGEPINCE AWEWLHRVVG DSRCTLVDTW 360
WQTETGGICI APRPSEEGAE ILPAMAMRPF FGIVPVLMDE KGSVVEGSNV SGALCISQAW 420
PGMARTIYGD HQRFVDAYFK AYPGYYFTGD GAYRTEGGYY QITGRMDDVI NISGHRLGTA 480
EIEDAIADHP AVPESAVIGY PHDIKGEAAF AFIVVKDSAG DSDVVVQELK SMVATKIAKY 540
AVPDEILVVK RLPKTRSGKV MRRLLRKIIT SEAQELGDTT TLEDPSIIAE ILSVYQKCKD 600
KQAAAK 606 
Gene Ontology
 GO:0003987; F:acetate-CoA ligase activity; IEA:InterPro.
 GO:0016208; F:AMP binding; IEA:InterPro.
 GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro. 
Interpro
 IPR011904; Ac_CoA_lig.
 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig.
 IPR025110; DUF4009. 
Pfam
 PF00501; AMP-binding
 PF13193; DUF4009 
SMART
  
PROSITE
 PS00455; AMP_BINDING 
PRINTS