UniProt Accession

 AES_MOUSE; P63002; Q06195 

Genbank Protein ID

 L12140; X73359; X73361 

Genbank Nucleotide ID

 AAA03023.1; CAA51769.1; CAA51771.1 

Protein Name

 Amino-terminal enhancer of split 

Protein Synonyms/Alias

 Amino enhancer of split; Grg-5; Protein ESP1; Protein GRG 

Gene Name

 Aes 

Gene Synonyms/Alias

 Esp1; Grg 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
19	SHLPQQLKFTTSDSC	ubiquitination	[1]
30	SDSCDRIKDEFQLLQ	ubiquitination	[1]
49	SLKLECDKLASEKSE	ubiquitination	[1]
54	CDKLASEKSEMQRHY	ubiquitination	[1]
112	LGAIERAKQVTAPEL	ubiquitination	[1, 2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state (By similarity). 

Sequence Annotation

 REGION 166 197 CCN domain.
 MOD_RES 196 196 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 197 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003714; F:transcription corepressor activity; IDA:MGI.
 GO:0031668; P:cellular response to extracellular stimulus; IDA:MGI.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0032091; P:negative regulation of protein binding; IEA:Compara.
 GO:0060761; P:negative regulation of response to cytokine stimulus; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:MGI.
 GO:2000210; P:positive regulation of anoikis; IEA:Compara.
 GO:0040008; P:regulation of growth; IMP:MGI.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0070555; P:response to interleukin-1; IEA:Compara.
 GO:0001501; P:skeletal system development; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR005617; Groucho/TLE_N. 

Pfam

 PF03920; TLE_N 

SMART

  

PROSITE

  

PRINTS