CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019897
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase 24 
Protein Synonyms/Alias
 Mammalian STE20-like protein kinase 3; MST-3; STE20-like kinase MST3; Serine/threonine-protein kinase 24 35 kDa subunit; Mammalian STE20-like protein kinase 3 N-terminal; MST3/N; Serine/threonine-protein kinase 24 12 kDa subunit; Mammalian STE20-like protein kinase 3 C-terminal; MST3/C 
Gene Name
 Stk24 
Gene Synonyms/Alias
 Mst3; Stk3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
226HSELHPMKVLFLIPKubiquitination[1]
233KVLFLIPKNNPPTLEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. Acts as a key regulator of axon regeneration in the optic nerve and radial nerve (By similarity). 
Sequence Annotation
 DOMAIN 24 274 Protein kinase.
 NP_BIND 30 38 ATP (By similarity).
 NP_BIND 100 102 ATP (By similarity).
 REGION 323 374 Nuclear export signal (NES) (By
 MOTIF 266 280 Bipartite nuclear localization signal (By
 ACT_SITE 144 144 Proton acceptor (By similarity).
 METAL 149 149 Magnesium (By similarity).
 METAL 162 162 Magnesium (By similarity).
 BINDING 53 53 ATP (By similarity).
 MOD_RES 4 4 Phosphoserine.
 MOD_RES 178 178 Phosphothreonine; by autocatalysis (By
 MOD_RES 308 308 Phosphoserine (By similarity).
 MOD_RES 341 341 Phosphothreonine.  
Keyword
 Apoptosis; ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 431 AA 
Protein Sequence
MAHSPVQSGL PGMQNLKADP EELFTKLEKI GKGSFGEVFK GIDNRTQKVV AIKIIDLEEA 60
EDEIEDIQQE ITVLSQCDSP YVTKYYGSYL KDTKLWIIME YLGGGSALDL LEPGPLDEIQ 120
IATILREILK GLDYLHSEKK IHRDIKAANV LLSEHGEVKL ADFGVAGQLT DTQIKRNTFV 180
GTPFWMAPEV IKQSAYDSKA DIWSLGITAI ELAKGEPPHS ELHPMKVLFL IPKNNPPTLE 240
GNYSKPLKEF VEACLNKEPS FRPTAKELLK HKFIIRNAKK TSYLTELIDR YKRWKAEQSH 300
EDSSSEDSDV ETDGQASGGS DSGDWIFTIR EKDPKNLENG TLQLSDLERN KMKDIPKRPF 360
SQCLSTIISP LFAELKEKSQ ACGGNLGSIE ELRGAIYLAE EACPGISDTM VAQLVQRLQR 420
YSLSGGGASA H 431 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; ISS:UniProtKB.
 GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.
 GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.
 GO:0048679; P:regulation of axon regeneration; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM 
PRINTS