| Tag | Content |
|---|
| CPLM ID | CPLM-005172 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta |
Protein Synonyms/Alias | GMP-PDE beta |
Gene Name | Pde6b |
Gene Synonyms/Alias | Mpb; Pdeb; rd |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 324 | IDYILHGKEDIKVIP | ubiquitination | [1] | | 611 | TNNLYQMKSQNPLAK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme. |
Sequence Annotation | DOMAIN 71 220 GAF 1.
DOMAIN 252 429 GAF 2.
ACT_SITE 557 557 Proton donor (By similarity).
METAL 561 561 Divalent metal cation 1 (By similarity).
METAL 597 597 Divalent metal cation 1 (By similarity).
METAL 598 598 Divalent metal cation 1 (By similarity).
METAL 598 598 Divalent metal cation 2 (By similarity).
METAL 718 718 Divalent metal cation 1 (By similarity).
MOD_RES 2 2 N-acetylserine (By similarity).
LIPID 853 853 S-geranylgeranyl cysteine (By |
Keyword | Acetylation; Alternative splicing; cGMP; Complete proteome; Hydrolase; Lipoprotein; Membrane; Metal-binding; Prenylation; Reference proteome; Repeat; Sensory transduction; Vision. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 856 AA |
Protein Sequence | MSLSEEQVRS FLDGNPTFAH QYFGKKLSPE NVAGACEDGW LADCGSLREL CQVEESAALF 60
ELVQDMQESV NMERVVFKIL RRLCTILHAD RCSLFMYRQR NGIAELATRL FSVQPDSLLE 120
DCLVPPDSEI VFPLDIGIVG HVAQTKKMIN VQDVAECPHF SSFADELTDY VTKNILSTPI 180
MNGKDVVAVI MAVNKLDGPC FTSEDEDVFT KYLNFATLNL KIYHLSYLHN CETRRGQVLL 240
WSANKVFEEL TDIERQFHKA FYTVRAYLNC ERYSVGLLDM TKEKEFFDVW PVLMGEAQPY 300
SGPRTPDGRE IVFYKVIDYI LHGKEDIKVI PTPPADHWAL ASGLPTYVAE SGFICNIMNA 360
SADEMFNFQE GPLDDSGWVI KNVLSMPIVN KKEEIVGVAT FYNRKDGKPF DDQDEVLMES 420
LTQFLGWSVL NTDTYDKMNK LENRKDIAQD MVLYHVRCDK DEIQEILPTR DRLGKEPADC 480
EEDELGKILK EELPGPTKFD IYEFHFSDLE CTELELVKCG IQMYYELGVV RKFQIPQEVL 540
VRFLFSVSKA YRRITYHNWR HGFNVAQTMF TLLMTGKLKS YYTDLEAFAM VTAGLCHDID 600
HRGTNNLYQM KSQNPLAKLH GSSILERHHL EFGKFLLAEE SLNIYQNLNR RQHEHVIHLM 660
DIAIIATDLA LYFKKRTMFQ KIVDESKNYE DKKSWVEYLS LETTRKEIVM AMMMTACDLS 720
AITKPWEVQS KVALLVAAEF WEQGDLERTV LDQQPIPMMD RNKAAELPKL QVGFIDFVCT 780
FVYKEFSRFH EEILPMFDRL QNNRKEWKAL ADEYEAKVKA LEEEKKKEED RVAAKKVGTE 840
VCNGGPAPKS STCCIL 856 |
Gene Ontology | GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0051480; P:cytosolic calcium ion homeostasis; IEA:Compara. GO:0009583; P:detection of light stimulus; IMP:MGI. GO:0046037; P:GMP metabolic process; IEA:Compara. GO:0060041; P:retina development in camera-type eye; IMP:MGI. GO:0007165; P:signal transduction; IEA:InterPro. GO:0007601; P:visual perception; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |