CPLM-009550

Genbank Nucleotide ID

Protein Synonyms/Alias

Granule cell differentiation protein; Protein V-1

Mus musculus (Mouse)

Position	Peptide	Type	References
4	****MCDKEFMWALK	acetylation	[1, 2, 3]
4	****MCDKEFMWALK	ubiquitination	[4]
11	KEFMWALKNGDLDEV	acetylation	[5]
19	NGDLDEVKDYVAKGE	acetylation	[5]
24	EVKDYVAKGEDVNRT	acetylation	[2, 6]

[1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
Simon GM, Cheng J, Gordon JI.
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
[2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
[3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
[4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
PLoS One. 2012;7(12):e50545. [PMID: 23236377]
[6] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]

Functional Description

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer.

REPEAT 2 30 ANK 1.
REPEAT 34 66 ANK 2.
REPEAT 67 99 ANK 3.
MOD_RES 2 2 N-acetylcysteine (By similarity).
MOD_RES 4 4 N6-acetyllysine (By similarity).
MOD_RES 11 11 N6-acetyllysine (By similarity).
MOD_RES 24 24 N6-acetyllysine (By similarity).

3D-structure; Acetylation; ANK repeat; Complete proteome; Cytoplasm; Nucleus; Reference proteome; Repeat.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0030424; C:axon; IEA:Compara.
GO:0005829; C:cytosol; ISS:UniProtKB.
GO:0008290; C:F-actin capping protein complex; IEA:Compara.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0006584; P:catecholamine metabolic process; IEA:Compara.
GO:0016049; P:cell growth; IEA:Compara.
GO:0021707; P:cerebellar granule cell differentiation; IEA:Compara.
GO:0010613; P:positive regulation of cardiac muscle hypertrophy; ISS:UniProtKB.
GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB.
GO:0010557; P:positive regulation of macromolecule biosynthetic process; ISS:UniProtKB.
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
GO:0051247; P:positive regulation of protein metabolic process; ISS:UniProtKB.
GO:2000812; P:regulation of barbed-end actin filament capping; ISS:UniProtKB.
GO:0043403; P:skeletal muscle tissue regeneration; IEA:Compara.
GO:0051146; P:striated muscle cell differentiation; IEA:Compara.

IPR002110; Ankyrin_rpt.
IPR020683; Ankyrin_rpt-contain_dom.

PS50297; ANK_REP_REGION
PS50088; ANK_REPEAT