| Tag | Content |
|---|
| CPLM ID | CPLM-014642 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Glycerol kinase |
Protein Synonyms/Alias | GK; Glycerokinase; ATP:glycerol 3-phosphotransferase |
Gene Name | Gk |
Gene Synonyms/Alias | Gyk |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 6 | **MAAAKKAVLGPLV | ubiquitination | [1] | | 31 | RFLVFNSKTAELLSH | ubiquitination | [1] | | 74 | CIEKTCEKLGQLNID | ubiquitination | [1] | | 86 | NIDISNIKAIGVSNQ | ubiquitination | [1] | | 128 | STVENLSKRIPGNNN | ubiquitination | [1] | | 140 | NNNFVKSKTGLPLST | ubiquitination | [1] | | 313 | LLTTVAYKLGRDKPV | ubiquitination | [1] | | 346 | RDNLGIIKSSEEIEK | ubiquitination | [1] | | 353 | KSSEEIEKLAKEVGT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). |
Sequence Annotation | NP_BIND 433 437 ATP (By similarity).
BINDING 20 20 Substrate (By similarity).
BINDING 24 24 ATP (By similarity).
BINDING 94 94 Substrate (By similarity).
BINDING 148 148 Substrate (By similarity).
BINDING 265 265 Substrate (By similarity).
BINDING 287 287 ATP (By similarity).
BINDING 332 332 ATP; via carbonyl oxygen (By similarity). |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Glycerol metabolism; Kinase; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 559 AA |
Protein Sequence | MAAAKKAVLG PLVGAVDQGT SSTRFLVFNS KTAELLSHHQ VEIKQEFPRE GWVEQDPKEI 60
LQSVYECIEK TCEKLGQLNI DISNIKAIGV SNQRETTVVW DKVTGEPLYN AVVWLDLRTQ 120
STVENLSKRI PGNNNFVKSK TGLPLSTYFS AVKLRWLLDN VKKVQEAVEE NRALFGTIDS 180
WLIWSLTGGI HGGVHCTDVT NASRTMLFNI HSLEWDKELC EFFGIPMEIL PNVRSSSEIY 240
GLMKISHSLK AGALEGVPIS GCLGDQSAAL VGQMCFQDGQ AKNTYGTGCF LLCNTGHKCV 300
FSEHGLLTTV AYKLGRDKPV YYALEGSVAI AGAVIRWLRD NLGIIKSSEE IEKLAKEVGT 360
SYGCYFVPAF SGLYAPYWEP SARGIICGLT QFTNKCHIAF AALEAVCFQT REILDAMNRD 420
CGIPLSHLQV DGGMTSNKIL MQLQADILYI PVVKPSMPET TALGAAMAAG AAEGVGVWSL 480
EPEDLSAVTM ERFEPQINAE ESEIRYSTWK KAVMKSIGWV TTQSPESGDP SIFCSLPLGF 540
FIVSSMVMLI GARYISGIP 559 |
Gene Ontology | GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IDA:MGI. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004370; F:glycerol kinase activity; IDA:MGI. GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway. GO:0006071; P:glycerol metabolic process; IMP:MGI. GO:0046167; P:glycerol-3-phosphate biosynthetic process; IEA:Compara. GO:0006641; P:triglyceride metabolic process; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |