CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025833
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isoleucyl-tRNA synthetase, cytoplasmic variant 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1068YPVSPSDKVLIQEKTubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aminoacyl-tRNA synthetase; Ligase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1279 AA 
Protein Sequence
ACWPAGLSRH ARPLSNKMLQ QVPENINFPA EEEKILEFWT EFNCFQECLK QSKHKPKFTF 60
YDGPPFATGL PHYGHILAGT IKDIVTRYAH QSGFHVDRRF GWDCHGLPVE YEIDKTLGIR 120
GPEDVAKMGI TEYNNQCRAI VMRYSAEWKS TVSRLGRWID FDNDYKTLYP QFMESVWWVF 180
KQLYDKGLVY RGVKVMPFST ACNTPLSNFE SHQNYKDVQD PSVFVTFPLE EDETVSLVAW 240
TTTPWTLPSN LAVCVNPEMQ YVKIKDVARG RLLILMEARL SALYKLESDY EILERFPGAY 300
LKGKKYRPLF DYFLKCKENG AFTVLVDNYV KEEEGTGVVH QAPYFGAEDY RVCMDFNIIR 360
KDSLPVCPVD ASGCFTTEVT DFAGQYVKDA DKSIIRTLKE QGRLLVATTF THSYPFCWRS 420
DTPLIYKAVP SWFVRVENMV DQLLRNNDLC YWVPELVREK RFGNWLKDAR DWTISRNRYW 480
GTPIPLWVSD DFEEVVCIGS VAELEELSGA KISDLHRESV DHLTIPSRCG KGSLHRISEV 540
FDCWFESGSM PYAQVHYPFE NKREFEDAFP ADFIAEGIDQ TRGWFYTLLV LATALFGQPP 600
FKNVIVNGLV LASDGQKMSK RKKNYPDPVS IIQKYGADAL RLYLINSPVV RAENLRFKEE 660
GVRDVLKDVL LPWYNAYRFL IQNVLRLQKE EEIEFLYNEN TVRESPNITD RWILSFMQSL 720
IGFFETEMAA YRLYTVVPRL VKFVDILTNW YVRMNRRRLK GENGMEDCVM ALETLFSVLL 780
SLCRLMAPYT PFLTELMYQN LKVLIDPVSV QDKDTLSIHY LMLPRVREEL IDKKTESAVS 840
QMQSVIELGR VIRDRKTIPI KYPLKEIVVI HQDPEALKDI KSLEKYIIEE LNVRKVTLST 900
DKNKYGIRLR AEPDHMVLGK RLKGAFKAVM TSIKQLSSEE LEQFQKTGTI VVEGHELHDE 960
DIRLMYTFDQ ATGGTAQFEA HSDAQALVLL DVTPDQSMVD EGMAREVINR IQKLRKKCNL 1020
VPTDEITVYY KAKSEGTYLN SVIESHTEFI FTTIKAPLKP YPVSPSDKVL IQEKTQLKGS 1080
ELEITLTRGS SLPGPACAYV NLNICANGSE QGGVLLLENP KGDNRLDLLK LKSVVTSIFG 1140
VKNTELAVFH DETEIQNQTD LLSLSGKTLC VTAGSAPSLI NSSSTLLCQY INLQLLNAKP 1200
QECLMGTVGT LLLENPLGQN GLTHQGLLYE AAKVFGLRSR KLKLFLNETQ TQEITEDIPV 1260
KTLNMKTVYV SVLPTTADF 1279 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004822; F:isoleucine-tRNA ligase activity; IEA:InterPro.
 GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
 GO:0006450; P:regulation of translational fidelity; IEA:GOC. 
Interpro
 IPR001412; aa-tRNA-synth_I_CS.
 IPR002300; aa-tRNA-synth_Ia.
 IPR002301; Ile-tRNA-ligase.
 IPR023586; Ile-tRNA-ligase_type2.
 IPR014729; Rossmann-like_a/b/a_fold.
 IPR009080; tRNAsynth_1a_anticodon-bd.
 IPR013155; V/L/I-tRNA-synth_anticodon-bd.
 IPR009008; Val/Leu/Ile-tRNA-synth_edit. 
Pfam
 PF08264; Anticodon_1
 PF00133; tRNA-synt_1 
SMART
  
PROSITE
 PS00178; AA_TRNA_LIGASE_I 
PRINTS
 PR00984; TRNASYNTHILE.