| Tag | Content |
|---|
| CPLM ID | CPLM-014873 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Acyl-coenzyme A synthetase ACSM5, mitochondrial |
Protein Synonyms/Alias | |
Gene Name | Acsm5 |
Gene Synonyms/Alias | Macs3 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 96 | WTFEELGKQSRKAAN | acetylation | [1] | | 151 | GISQLTQKDLKYRLQ | acetylation | [1] | | 540 | RELQEHVKTVTAPYK | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity). |
Sequence Annotation | NP_BIND 229 237 ATP (By similarity).
NP_BIND 367 372 ATP (By similarity).
BINDING 454 454 ATP (By similarity).
BINDING 469 469 ATP (By similarity).
BINDING 565 565 ATP (By similarity). |
Keyword | ATP-binding; Complete proteome; Fatty acid metabolism; GTP-binding; Ligase; Lipid metabolism; Magnesium; Metal-binding; Mitochondrion; Nucleotide-binding; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 578 AA |
Protein Sequence | MRLWLRGLVY QARRSSWGVF RIHTQPPPPP IPEVVATWEA ISLGKRPVPE YFNFAHDVLD 60
VWSQLEKTGH RPPNPAFWWV NGSGTEVKWT FEELGKQSRK AANILEGACG LKPGDRLMLV 120
LPRLPEWWLT IVACMRTGVV MIPGISQLTQ KDLKYRLQAA RVKSIITSDA LAPHVDAISA 180
DCPSLQSRLL VSDTSRPGWI NFRELLRVAS PEHNCLRTRS GDSMAIYFTS GTTGTPKMVE 240
HSQCSYGLGF VASGRRLMAL TESDIFWNTT DTGWVKAAWT LFSAWANGAC VFVHELPQVD 300
AQTILNTLCR FPITTICCVP TLFRLLVQED LTRYKFQCLR HCLAGGEALN SDVRDKWKNQ 360
TGLEIHEGYG QSETVLICGN FRGSTIKSGS MGKASPPYDV QIVDEEGNVL PPGKEGNIAI 420
RIKPTRPFCL FNCYLDNPEK TAASEQGDFY ITGDRAHMDE DGYFWFVGRN DDVINSSSYR 480
IGPVEVESAL AEHPAVLESA VVSSPDPIRG EVVKAFIVLS PAYVSHDPEA LTRELQEHVK 540
TVTAPYKYPR KVAFISELPK TVSGKILRSK LRNQEWGR 578 |
Gene Ontology | GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0047760; F:butyrate-CoA ligase activity; IEA:EC. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |