UniProt Accession

 FOS_HUMAN; P01100; P18849 

Genbank Protein ID

 V01512; K00650; AY212879; AF111167; BC004490; S65138 

Genbank Nucleotide ID

 CAA24756.1; AAA52471.1; AAO21129.1; AAC98315.1; AAH04490.1; AAB20306.1 

Protein Name

 Proto-oncogene c-Fos 

Protein Synonyms/Alias

 Cellular oncogene fos; G0/G1 switch regulatory protein 7 

Gene Name

 FOS 

Gene Synonyms/Alias

 G0S7 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
265	SISSMELKTEPFDDF	sumoylation	[1]

Reference

 [1] Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.
 Bossis G, Malnou CE, Farras R, Andermarcher E, Hipskind R, Rodriguez M, Schmidt D, Muller S, Jariel-Encontre I, Piechaczyk M.
 Mol Cell Biol. 2005 Aug;25(16):6964-79. [PMID: 16055710] 

Functional Description

 Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. 

Sequence Annotation

 DOMAIN 137 200 bZIP.
 REGION 139 159 Basic motif; required for the activation
 REGION 165 193 Leucine-zipper (By similarity).
 MOD_RES 10 10 Phosphotyrosine; by SRC.
 MOD_RES 30 30 Phosphotyrosine; by SRC.
 MOD_RES 232 232 Phosphothreonine (By similarity).
 MOD_RES 325 325 Phosphothreonine; by MAPK1 and MAPK3.
 MOD_RES 331 331 Phosphothreonine; by MAPK1 and MAPK3.
 MOD_RES 362 362 Phosphoserine; by MAPK1, MAPK3 and
 MOD_RES 374 374 Phosphoserine; by MAPK1 and MAPK3.
 CROSSLNK 113 113 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 265 265 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Complete proteome; Cytoplasm; DNA-binding; Endoplasmic reticulum; Isopeptide bond; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 380 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0003690; F:double-stranded DNA binding; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
 GO:0007568; P:aging; IEA:Compara.
 GO:0071277; P:cellular response to calcium ion; IEA:Compara.
 GO:0031668; P:cellular response to extracellular stimulus; IEA:Compara.
 GO:0032870; P:cellular response to hormone stimulus; IEA:Compara.
 GO:0034614; P:cellular response to reactive oxygen species; IDA:BHF-UCL.
 GO:0001661; P:conditioned taste aversion; IEA:Compara.
 GO:0006306; P:DNA methylation; TAS:ProtInc.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0006954; P:inflammatory response; TAS:ProtInc.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.
 GO:0007399; P:nervous system development; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.
 GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; TAS:Reactome.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0009409; P:response to cold; IEA:Compara.
 GO:0051412; P:response to corticosterone stimulus; IEA:Compara.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0009629; P:response to gravity; IEA:Compara.
 GO:0009416; P:response to light stimulus; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0032570; P:response to progesterone stimulus; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0030431; P:sleep; IEA:Compara.
 GO:0060395; P:SMAD protein signal transduction; IDA:BHF-UCL.
 GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.
 GO:0034166; P:toll-like receptor 10 signaling pathway; TAS:Reactome.
 GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.
 GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.
 GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
 GO:0034146; P:toll-like receptor 5 signaling pathway; TAS:Reactome.
 GO:0034162; P:toll-like receptor 9 signaling pathway; TAS:Reactome.
 GO:0038123; P:toll-like receptor TLR1:TLR2 signaling pathway; TAS:Reactome.
 GO:0038124; P:toll-like receptor TLR6:TLR2 signaling pathway; TAS:Reactome.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IDA:BHF-UCL.
 GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome. 

Interpro

 IPR004827; bZIP.
 IPR000837; Leuzip_Fos. 

Pfam

 PF00170; bZIP_1 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS

 PR00042; LEUZIPPRFOS.