| Tag | Content |
|---|
| CPLM ID | CPLM-022779 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Aspartoacylase |
Protein Synonyms/Alias | Aminoacylase-2; ACY-2 |
Gene Name | Aspa |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 48 | HRAGLEVKPFITNPR | acetylation | [1] | | 171 | ATTRSIAKYPVGIEV | acetylation | [1] | | 227 | DVYKIMEKVDYPRNE | acetylation | [1] | | 296 | EKKEAFAKTTKLTLN | acetylation | [1] | | 299 | EAFAKTTKLTLNAKS | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter (By similarity). |
Sequence Annotation | REGION 69 70 Substrate binding (By similarity).
REGION 163 167 Substrate binding (By similarity).
ACT_SITE 177 177 By similarity.
METAL 20 20 Zinc.
METAL 23 23 Zinc.
METAL 115 115 Zinc.
BINDING 62 62 Substrate (By similarity).
BINDING 177 177 Substrate (By similarity).
BINDING 287 287 Substrate (By similarity). |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Metal-binding; Nucleus; Reference proteome; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 312 AA |
Protein Sequence | MTSCVAEEPI KKIAIFGGTH GNELTGVFLV THWLKNGAEV HRAGLEVKPF ITNPRAVEKC 60
TRYIDCDLNR VFDLENLSKE MSEDLPYEVR RAQEINHLFG PKNSDDAYDV VFDLHNTTSN 120
MGCTLILEDS RNDFLIQMFH YIKTCMAPLP CSVYLIEHPS LKYATTRSIA KYPVGIEVGP 180
QPHGVLRADI LDQMRRMLKH ALDFIQRFNE GKEFPPCAID VYKIMEKVDY PRNESGDVAA 240
VIHPNLQDQD WKPLHPGDPV FVSLDGKVIP LGGDCTVYPV FVNEAAYYEK KEAFAKTTKL 300
TLNAKSIRST LH 312 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:RGD. GO:0005634; C:nucleus; IDA:RGD. GO:0019807; F:aspartoacylase activity; TAS:RGD. GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0022010; P:central nervous system myelination; IEP:RGD. GO:0048714; P:positive regulation of oligodendrocyte differentiation; IMP:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |