UniProt Accession

 B2R4R0_HUMAN; B2R4R0 

Genbank Protein ID

 BC148271; AK311916; AK312028; AK312153; AK316561; AB451459 

Genbank Nucleotide ID

 AAI48272.1; BAG34857.1; BAG34965.1; BAG35087.1; BAG38150.1; BAG70273.1 

Protein Name

 Histone H4 

Protein Synonyms/Alias

  

Gene Name

 HIST1H4L 

Gene Synonyms/Alias

 HIST1H4J 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
32	DNIQGITKPAIRRLA	ubiquitination	[1, 2]
60	EETRGVLKVFLENVI	ubiquitination	[1, 2]
78	VTYTEHAKRKTVTAM	ubiquitination	[1, 2]
80	YTEHAKRKTVTAMDV	ubiquitination	[1, 2]
92	MDVVYALKRQGRTLY	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). 

Sequence Annotation

  

Keyword

 Chromosome; DNA-binding; Nucleosome core; Nucleus. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 103 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR001951; Histone_H4.
 IPR019809; Histone_H4_CS. 

Pfam

 PF00125; Histone 

SMART

 SM00417; H4 

PROSITE

 PS00047; HISTONE_H4 

PRINTS

 PR00623; HISTONEH4.