UniProt Accession

 RBMX_RAT; Q4V898 

Genbank Protein ID

 CH474106; BC097479 

Genbank Nucleotide ID

 EDL75123.1; AAH97479.1 

Protein Name

 RNA-binding motif protein, X chromosome 

Protein Synonyms/Alias

 Heterogeneous nuclear ribonucleoprotein G; hnRNP G; RNA-binding motif protein, X chromosome retrogene; RNA-binding motif protein, X chromosome retrogene-like; RNA-binding motif protein, X chromosome, N-terminally processed 

Gene Name

 Rbmx 

Gene Synonyms/Alias

 Rbmxrt 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
63	FESPADAKDAARDMN	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'- CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non- specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. 

Sequence Annotation

 DOMAIN 8 86 RRM.
 MOD_RES 1 1 N-acetylmethionine; in Heterogeneous
 MOD_RES 2 2 N-acetylvaline; in Heterogeneous nuclear
 MOD_RES 30 30 N6-acetyllysine (By similarity).
 MOD_RES 88 88 Phosphoserine (By similarity).
 MOD_RES 168 168 Phosphoserine (By similarity).
 MOD_RES 185 185 Omega-N-methylated arginine (By
 MOD_RES 208 208 Phosphoserine (By similarity).
 MOD_RES 329 329 Phosphoserine (By similarity).
 MOD_RES 332 332 Phosphoserine (By similarity).
 MOD_RES 352 352 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Glycoprotein; Methylation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repressor; Ribonucleoprotein; RNA-binding; Spliceosome; Transcription; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 390 AA 

Protein Sequence

Gene Ontology

 GO:0005681; C:spliceosomal complex; IDA:RGD.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003727; F:single-stranded RNA binding; IDA:RGD.
 GO:0006376; P:mRNA splice site selection; IMP:RGD.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:RGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR012604; RBM1CTR.
 IPR000504; RRM_dom. 

Pfam

 PF08081; RBM1CTR
 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS