CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005000
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 C5a anaphylatoxin chemotactic receptor 1 
Protein Synonyms/Alias
 C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD88 
Gene Name
 C5AR1 
Gene Synonyms/Alias
 C5AR; C5R1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
346TVDTMAQKTQAV***ubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. 
Sequence Annotation
 MOD_RES 11 11 Sulfotyrosine.
 MOD_RES 14 14 Sulfotyrosine.
 MOD_RES 314 314 Phosphoserine (Probable).
 MOD_RES 317 317 Phosphoserine (Probable).
 MOD_RES 327 327 Phosphoserine (Probable).
 MOD_RES 332 332 Phosphoserine (Probable).
 MOD_RES 334 334 Phosphoserine (Probable).
 MOD_RES 338 338 Phosphoserine (Probable).
 CARBOHYD 5 5 N-linked (GlcNAc...) (Potential).
 DISULFID 109 188 By similarity.  
Keyword
 Cell membrane; Chemotaxis; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Sulfation; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 350 AA 
Protein Sequence
MDSFNYTTPD YGHYDDKDTL DLNTPVDKTS NTLRVPDILA LVIFAVVFLV GVLGNALVVW 60
VTAFEAKRTI NAIWFLNLAV ADFLSCLALP ILFTSIVQHH HWPFGGAACS ILPSLILLNM 120
YASILLLATI SADRFLLVFK PIWCQNFRGA GLAWIACAVA WGLALLLTIP SFLYRVVREE 180
YFPPKVLCGV DYSHDKRRER AVAIVRLVLG FLWPLLTLTI CYTFILLRTW SRRATRSTKT 240
LKVVVAVVAS FFIFWLPYQV TGIMMSFLEP SSPTFLLLKK LDSLCVSFAY INCCINPIIY 300
VVAGQGFQGR LRKSLPSLLR NVLTEESVVR ESKSFTRSTV DTMAQKTQAV 350 
Gene Ontology
 GO:0045177; C:apical part of cell; IDA:UniProtKB.
 GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0004944; F:C5a anaphylatoxin receptor activity; IDA:UniProtKB.
 GO:0004878; F:complement component C5a receptor activity; IDA:UniProtKB.
 GO:0004982; F:N-formyl peptide receptor activity; IEA:InterPro.
 GO:0000187; P:activation of MAPK activity; TAS:ProtInc.
 GO:0007202; P:activation of phospholipase C activity; TAS:ProtInc.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0021534; P:cell proliferation in hindbrain; IEA:Compara.
 GO:0006968; P:cellular defense response; TAS:ProtInc.
 GO:0006935; P:chemotaxis; TAS:ProtInc.
 GO:0050830; P:defense response to Gram-positive bacterium; IEA:Compara.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; TAS:ProtInc.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:0006954; P:inflammatory response; IEA:Compara.
 GO:0042789; P:mRNA transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0030593; P:neutrophil chemotaxis; IEA:Compara.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0050679; P:positive regulation of epithelial cell proliferation; IDA:UniProtKB.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0032494; P:response to peptidoglycan; IEA:Compara.
 GO:0007606; P:sensory perception of chemical stimulus; TAS:ProtInc. 
Interpro
 IPR002234; Anphylx_rcpt.
 IPR001274; C5A_anaphtx_rcpt.
 IPR000826; Formyl_pep_rcpt.
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM. 
Pfam
 PF00001; 7tm_1 
SMART
  
PROSITE
 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 
PRINTS
 PR01104; ANPHYLATOXNR.
 PR00426; C5ANPHYLTXNR.
 PR00237; GPCRRHODOPSN.