| Tag | Content |
|---|
| CPLM ID | CPLM-020310 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sphingosine-1-phosphate phosphatase 1 |
Protein Synonyms/Alias | SPPase1; Spp1; hSPP1; hSPPase1; Sphingosine-1-phosphatase 1 |
Gene Name | SGPP1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 19 | GRLQDPQKVARFQRL | ubiquitination | [1] | | 393 | ITIPLACKIFNIPCD | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Has enzymatic activity against both sphingosine 1- phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels. |
Sequence Annotation | MOD_RES 101 101 Phosphoserine.
MOD_RES 112 112 Phosphoserine.
MOD_RES 114 114 Phosphothreonine. |
Keyword | Complete proteome; Endoplasmic reticulum; Hydrolase; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 441 AA |
Protein Sequence | MSLRQRLAQL VGRLQDPQKV ARFQRLCGVE APPRRSADRR EDEKAEAPLA GDPRLRGRQP 60
GAPGGPQPPG SDRNQCPAKP DGGGAPNGVR NGLAAELGPA SPRRAGALRR NSLTGEEGQL 120
ARVSNWPLYC LFCFGTELGN ELFYILFFPF WIWNLDPLVG RRLVVIWVLV MYLGQCTKDI 180
IRWPRPASPP VVKLEVFYNS EYSMPSTHAM SGTAIPISMV LLTYGRWQYP LIYGLILIPC 240
WCSLVCLSRI YMGMHSILDI IAGFLYTILI LAVFYPFVDL IDNFNQTHKY APFIIIGLHL 300
ALGIFSFTLD TWSTSRGDTA EILGSGAGIA CGSHVTYNMG LVLDPSLDTL PLAGPPITVT 360
LFGKAILRIL IGMVFVLIIR DVMKKITIPL ACKIFNIPCD DIRKARQHME VELPYRYITY 420
GMVGFSITFF VPYIFFFIGI S 441 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0042392; F:sphingosine-1-phosphate phosphatase activity; IEA:Compara. GO:0006915; P:apoptotic process; IEA:Compara. GO:0044281; P:small molecule metabolic process; TAS:Reactome. GO:0006668; P:sphinganine-1-phosphate metabolic process; IEA:Compara. GO:0030148; P:sphingolipid biosynthetic process; TAS:Reactome. GO:0006670; P:sphingosine metabolic process; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |