UniProt Accession

 EF1D_RAT; Q68FR9 

Genbank Protein ID

 CH473950; BC079391 

Genbank Nucleotide ID

 EDM16037.1; AAH79391.1 

Protein Name

 Elongation factor 1-delta 

Protein Synonyms/Alias

 EF-1-delta 

Gene Name

 Eef1d 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
17	KIWFDKFKYDDAERR	acetylation	[1]
107	DLQQAISKLEVRLST	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome (By similarity). 

Sequence Annotation

 REGION 80 115 Leucine-zipper (By similarity).
 REGION 173 281 Catalytic (GEF) (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 17 17 N6-acetyllysine (By similarity).
 MOD_RES 107 107 N6-acetyllysine (By similarity).
 MOD_RES 117 117 N6-acetyllysine (By similarity).
 MOD_RES 129 129 Phosphothreonine (By similarity).
 MOD_RES 133 133 Phosphoserine (By similarity).
 MOD_RES 147 147 Phosphothreonine (By similarity).
 MOD_RES 162 162 Phosphoserine; by CK2.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; DNA-binding; Elongation factor; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 281 AA 

Protein Sequence

Gene Ontology

 GO:0005853; C:eukaryotic translation elongation factor 1 complex; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; IEA:Compara.
 GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR018940; EF-1_beta_acid_region_euk.
 IPR014717; Transl_elong_EF1B/ribosomal_S6.
 IPR001326; Transl_elong_EF1B_B/D_CS.
 IPR014038; Transl_elong_fac_EF1B_bsu/dsu. 

Pfam

 PF10587; EF-1_beta_acid
 PF00736; EF1_GNE 

SMART

 SM00888; EF1_GNE 

PROSITE

 PS00825; EF1BD_2 

PRINTS