CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038094
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Eukaryotic translation initiation factor 4 gamma 1 
Protein Synonyms/Alias
  
Gene Name
 Eif4g1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
521KIKELNKKEAVGDLLubiquitination[1]
590NIQPGEQKYEYKSDQacetylation[2]
590NIQPGEQKYEYKSDQubiquitination[1]
594GEQKYEYKSDQWKPLubiquitination[1]
599EYKSDQWKPLNLEEKacetylation[3]
599EYKSDQWKPLNLEEKubiquitination[1]
768RVRSILNKLTPQMFQubiquitination[1]
793IDTEERLKGVIDLIFubiquitination[1]
879AEERGRLKEELEEARubiquitination[1]
898RRSLGNIKFIGELFKacetylation[2]
898RRSLGNIKFIGELFKubiquitination[1]
948GKDLDFAKAKPRMDQacetylation[3]
948GKDLDFAKAKPRMDQubiquitination[1]
962QYFNQMEKIIKEKKTacetylation[2]
1072SRLTKITKPGSIDSNacetylation[3]
1072SRLTKITKPGSIDSNubiquitination[1]
1184ATKRSFSKEVEERSRacetylation[3]
1443ELRRQLEKLLKDGGSacetylation[4, 5]
1507VRARLLQKYLCDEQKacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1594 AA 
Protein Sequence
MNKAPQPTGP PPARSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQH FYPSRAQPPS 60
SAASRVQSAA PARPGPAPHV YPAGSQVMMI PSQISYSASQ GAYYIPGQGR STYVVPTQQY 120
PVQPGAPGFY PGASPTEFGT YAGAYYPAQG VQQFPASVAP APVLMNQPPQ IAPKRERKTI 180
RIRDPNQGGK DITEEIMSGA RTASTPTPPQ TGGSLEPQPN GESPQVAVII RPDDRSQGAA 240
IGGRPGLPGP EHSPGTESQP SSPSPTPSPP PILEPGSESN LGVLSIPGDT MTTGMIPMSV 300
EESTPISCET GEPYCLSPEP TLAEPILEVE VTLSKPIPES EFSSSPLQVS TALVPHKVET 360
HEPNGVIPSE DLEPEVESST EPAPPPLSPC ASESLVPIAP TAQPEELLNG APSPPAVDLS 420
PVSEPEEQAK KVSSAALASI LSPAPPVAPS DTSPAQEEEM EEDDDDEEGG EAESEKGGED 480
VPLDSTPVPA QLSQNLEVAA ATQVAVSVPK RRRKIKELNK KEAVGDLLDA FKEVDPAVPE 540
VENQPPTGSN PSPESEGSMV PTQPEETEET WDSKEDKIHN AENIQPGEQK YEYKSDQWKP 600
LNLEEKKRYD REFLLGFQFI FASMQKPEGL PHITDVVLDK ANKTPLRQLD PSRLPGINCG 660
PDFTPSFANL GRPALSNRGP PRGGPGGELP RGPQAGLGPR RSQQGPRKET RKIISSVIMT 720
EDIKLNKAEK AWKPSSKRTA ADKDRGEEDA DGSKTQDLFR RVRSILNKLT PQMFQQLMKQ 780
VTQLAIDTEE RLKGVIDLIF EKAISEPNFS VAYANMCRCL MALKVPTTEK PTVTVNFRKL 840
LLNRCQKEFE KDKDDDEVFE KKQKEMDEAA TAEERGRLKE ELEEARDIAR RRSLGNIKFI 900
GELFKLKMLT EAIMHDCVVK LLKNHDEESL ECLCRLLTTI GKDLDFAKAK PRMDQYFNQM 960
EKIIKEKKTS SRIRFMLQDV LDLRQSNWVP RRGDQGPKTI DQIHKEAEME EHREHIKVQQ 1020
LMAKGSDKRR GGPPGPPINR GLPLVDDGGW NTVPISKGSR PIDTSRLTKI TKPGSIDSNN 1080
QLFAPGGRLS WGKGSSGGSG AKPSDTASEA TRPATLNRFS ALQQTLPAEN TDNRRVVQRS 1140
SLSRERGEKA GDRGDRLERS ERGGDRGDRL DRARTPATKR SFSKEVEERS RERPSQPEGL 1200
RKAASLTEDR GRDPVKREAT LPPVSPPKAA LSVDEVEKKS KAIIEEYLHL NDMKEAVQCV 1260
QELASPSLLF IFVRLGIEST LERSTIAREH MGRLLHQLLC AGHLSTAQYY QGLYETLELA 1320
EDMEIDIPHV WLYLAELITP ILQEDGVPMG ELFREITKPL RPMGKATSLL LEILGLLCKS 1380
MGPKKVGMLW REAGLSWREF LAEGQDVGSF VAEKKVEYTL GEESEAPGQR TLAFEELRRQ 1440
LEKLLKDGGS NQRVFDWIDA NLNEQQIASN TLVRALMTTV CYSAIIFETP LRVDVQVLKV 1500
RARLLQKYLC DEQKELQALY ALQALVVTLE QPANLLRMFF DALYDEDVVK EDAFYSWESS 1560
KDPAEQQGKG VALKSVTAFF NWLREAEDEE SDHN 1594 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0016070; P:RNA metabolic process; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR003891; Initiation_fac_eIF4g_MI.
 IPR016021; MIF4-like_typ_1/2/3.
 IPR003890; MIF4G-like_typ-3.
 IPR003307; W2_domain. 
Pfam
 PF02847; MA3
 PF02854; MIF4G
 PF02020; W2 
SMART
 SM00515; eIF5C
 SM00544; MA3
 SM00543; MIF4G 
PROSITE
 PS51366; MI
 PS51363; W2 
PRINTS