| Tag | Content |
|---|
| CPLM ID | CPLM-014851 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Macrophage-capping protein |
Protein Synonyms/Alias | Actin regulatory protein CAP-G |
Gene Name | Capg |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 139 | TTPAAIRKLYQVKGK | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. Uncapping occurs either when Ca(2+) falls or when the concentration of polyphosphoinositide rises, both at low and high Ca(2+) (By similarity). |
Sequence Annotation | REPEAT 28 107 Gelsolin-like 1.
REPEAT 147 222 Gelsolin-like 2.
REPEAT 264 342 Gelsolin-like 3.
MOTIF 138 147 Nuclear localization signal (Potential).
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 338 338 Phosphoserine. |
Keyword | Acetylation; Actin capping; Actin-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Secreted. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 349 AA |
Protein Sequence | MYTPIPQSGS PFPASVQDPG LHIWRVEKLK PVPIARENHG IFFSGDSYLV LHNGPEEASH 60
LHLWIGQQSS RDEQGACAVL AVHLNTLLGE RPVQHREVQG NESDLFMSYF PQGLKYREGG 120
VESAFHKTTS GTTPAAIRKL YQVKGKKNIR ATERALSWDS FNTGDCFILD LGQNIFAWCG 180
GKSNILERNK ARDLALAIRD SERQGKAQVE IITDGEEPAE MIQVLGPKPA LKEGNPEEDI 240
TADQTNAQAA ALYKVSDATG QMNLTKVADS SPFASELLIP DDCFVLDNGL CGKIYIWKGR 300
KANEKERQAA LQVADGFISR MRYSPNTQVE ILPQGRESPI FKQFFKDWK 349 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |