| Tag | Content |
|---|
| CPLM ID | CPLM-013155 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sorbin and SH3 domain-containing protein 2 |
Protein Synonyms/Alias | Arg/Abl-interacting protein 2; ArgBP2 |
Gene Name | Sorbs2 |
Gene Synonyms/Alias | Argbp2; Kiaa0777 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 488 | GSSSTFTKSFISSSP | ubiquitination | [1] | | 918 | QTEKAKCKASVVEAL | ubiquitination | [1] | | 1293 | TFPGNYVKRL***** | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1 (By similarity). |
Sequence Annotation | DOMAIN 166 230 SoHo.
DOMAIN 943 1002 SH3 1.
DOMAIN 1018 1079 SH3 2.
DOMAIN 1121 1180 SH3 3.
MOD_RES 27 27 Phosphoserine.
MOD_RES 40 40 Phosphoserine.
MOD_RES 130 130 Phosphoserine.
MOD_RES 239 239 Phosphoserine.
MOD_RES 339 339 Phosphoserine.
MOD_RES 357 357 Phosphothreonine (By similarity).
MOD_RES 358 358 Phosphoserine.
MOD_RES 378 378 Phosphoserine.
MOD_RES 379 379 Phosphoserine.
MOD_RES 381 381 Phosphoserine (By similarity).
MOD_RES 382 382 Phosphoserine.
MOD_RES 451 451 Phosphothreonine.
MOD_RES 456 456 Phosphoserine.
MOD_RES 829 829 Phosphoserine.
MOD_RES 1097 1097 Phosphoserine.
MOD_RES 1098 1098 Phosphoserine. |
Keyword | Alternative splicing; Cell junction; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome; Repeat; SH3 domain; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1180 AA |
Protein Sequence | MNTDSGGCAR KRAAMSVTLT SVKRVQSSPN LLAAGRESQS PDSAWRSYND RNPETLNGDA 60
TYSSLAAKGF RSVRPNLQDK RSPTQSQITI NGNSGGAVSP VSYYQRPFSP SAYSLPASLN 120
SSIIMQHGRS LDSAETYSQH AQSLDGTMGS SIPLYRSSEE EKRVTVIKAP HYPGIGPVDE 180
SGIPTAIRTT VDRPKDWYKT MFKQIHMVHK PDEDTDMYNT PYTYNAGLYN SPYSAQSHPA 240
AKTQTYRPLS KSHSDNGTDA FKEVPSPVPP PHVPPRPRDQ SSTLKHDWDP PDRKVDTRKF 300
RSEPRSIFEY EPGKSSILQH ERPPPLPPTP TPVPREPSRK PLSVSPSTDG LRSPSPPPRS 360
CVPAPRPSAP DLSPTRTGRI NPADIDLENE PWYKFFSELE FGHPPPKKAL DYVQDHSSGV 420
SNEVSIYQSS IDRSLERPSS SASMAGDFRK RRKSEPAVGP LRGLGDQSSS RTSPGRADLP 480
GSSSTFTKSF ISSSPSSPSR AQGGDDSKMC PPLCSYSGLN GTPSGELECC NAYRQHLDVP 540
GDSQRAITFK NGWQMARQNA EIWSSTEETV SPKIKSRSCD DLLNDDCDSF PDPKTKSESM 600
GSLLCEEDSK ESCPMTWASP YIQEVCGNSR SRLKHRSAHN APGFLKMYKK MHRINRKDLM 660
NSEVICSVKS RILQYEKEQQ HRGLLHGWSQ SSTEEVPRDV VPTRISEFEK LIQKSKSMPN 720
LGDEMLSPIT LEPPQNGLCP KRRFSIESLL EEETQVRHPS QGQRSCKSNT LVPIHIEVTS 780
DEQPRTHMEF SDSDQDGVVS DHSDYVHVEG SSFCSESDFD HFSFTSSESF YGSSHHHHHH 840
HHHHRHLISS CKGRCPASYT RFTTMLKHER AKHENMDRPR RQEMDPGLSK LAFLVSPVPF 900
RRKKILTPQK QTEKAKCKAS VVEALDSALK DICDQIKAEK RRGSLPDNSI LHRLISELLP 960
QIPERNSSLH ALKRSPMHQP FHPLPPDGAS HCPLYQNDCG RMPHSASFPD VDTTSNYHAQ 1020
DYGSALSLQD HESPRSYSST LTDLGRSASR ERRGTPEKEK LPAKAVYDFK AQTSKELSFK 1080
KGDTVYILRK IDQNWYEGEH HGRVGIFPIS YVEKLTPPEK AQPARPPPPV QPGEIGEAIA 1140
KYNFNADTNV ELSLRKGDRI ILLKRVDQNW YEGKIPGTNR QGIFPVSYVE VVKRNAKGAE 1200
DYPDPPLPHS YSSDRIYTLS SNKPQRPGFS HENIQGGGEP FQALYNYTPR NEDELELRES 1260
DVVDVMEKCD DGWFVGTSRR TKFFGTFPGN YVKRL 1295 |
Gene Ontology | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell. GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IDA:MGI. GO:0030018; C:Z disc; IEA:UniProtKB-SubCell. GO:0008270; F:zinc ion binding; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |