UniProt Accession

 NDUS2_MOUSE; Q91WD5; Q3TNA8; Q3U5Y9; Q3UJX7; Q99L23 

Genbank Protein ID

 AK078474; AK146269; AK150431; AK151746; AK153364; AK165426; BC003898; BC016097 

Genbank Nucleotide ID

 BAC37293.1; BAE27028.1; BAE29554.1; BAE30656.1; BAE31936.1; BAE38181.1; AAH03898.1; AAH16097.1 

Protein Name

 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial 

Protein Synonyms/Alias

 Complex I-49kD; CI-49kD; NADH-ubiquinone oxidoreductase 49 kDa subunit 

Gene Name

 Ndufs2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
62	SKETAHWKPPPWNDV	acetylation	[1]
304	GIQWDLRKTQPYDVY	ubiquitination	[2]
350	IIEQCLNKMPPGEIK	acetylation	[1]
437	AHLAGLDKMSKGHML	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). 

Sequence Annotation

 METAL 326 326 Iron-sulfur (4Fe-4S) (Potential).
 METAL 332 332 Iron-sulfur (4Fe-4S) (Potential).
 METAL 347 347 Iron-sulfur (4Fe-4S) (Potential).  

Keyword

 4Fe-4S; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase; Reference proteome; Respiratory chain; Transit peptide; Transport; Ubiquinone. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 463 AA 

Protein Sequence

Gene Ontology

 GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:EC.
 GO:0048038; F:quinone binding; IEA:InterPro.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0006979; P:response to oxidative stress; ISS:UniProtKB. 

Interpro

 IPR001135; NADH_Q_OxRdtase_suD.
 IPR014029; NADH_UbQ_OxRdtase_49kDa_CS.
 IPR022885; NDH1_su_D/H. 

Pfam

 PF00346; Complex1_49kDa 

SMART

  

PROSITE

 PS00535; COMPLEX1_49K 

PRINTS