UniProt Accession

 PEPB_ECOLI; P37095; P76580; P76989; P76991; Q47131 

Genbank Protein ID

 D84499; U00096; AP009048; U01827 

Genbank Nucleotide ID

 BAA12689.1; AAC75576.2; BAA16413.1 

Protein Name

 Peptidase B 

Protein Synonyms/Alias

 Aminopeptidase B 

Gene Name

 pepB 

Gene Synonyms/Alias

 yfhI; b2523; JW2507 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
50	LIQRAARKIDGLGIK	acetylation	[1]
57	KIDGLGIKHVQLSGE	acetylation	[1, 2]
86	KAPKGTRKVVWPDLD	acetylation	[2]
148	RVTYRITKGEDLREQ	acetylation	[1, 2]
184	DYNPTGDKEAPVYAC	acetylation	[1]
242	RGLNKRVKLFLCCAD	acetylation	[1]
270	ITYRNGKKVEVMNTD	acetylation	[2]
295	LIDASAQKPEMIIDA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 Probably plays an important role in intracellular peptide degradation (By similarity). 

Sequence Annotation

 ACT_SITE 207 207 Potential.
 ACT_SITE 281 281 Potential.
 METAL 195 195 Manganese 2 (By similarity).
 METAL 200 200 Manganese 1 (By similarity).
 METAL 200 200 Manganese 2 (By similarity).
 METAL 218 218 Manganese 2 (By similarity).
 METAL 277 277 Manganese 1 (By similarity).
 METAL 279 279 Manganese 1 (By similarity).
 METAL 279 279 Manganese 2 (By similarity).  

Keyword

 Aminopeptidase; Complete proteome; Cytoplasm; Hydrolase; Manganese; Metal-binding; Protease; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 427 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0004177; F:aminopeptidase activity; IEA:HAMAP.
 GO:0030145; F:manganese ion binding; IEA:HAMAP.
 GO:0008235; F:metalloexopeptidase activity; IEA:InterPro.
 GO:0043171; P:peptide catabolic process; IGI:EcoliWiki.
 GO:0006508; P:proteolysis; IEA:HAMAP. 

Interpro

 IPR011356; Leucine_aapep/pepB.
 IPR008330; Pept_M17_PepB.
 IPR000819; Peptidase_M17_C. 

Pfam

 PF12404; DUF3663
 PF00883; Peptidase_M17 

SMART

  

PROSITE

 PS00631; CYTOSOL_AP 

PRINTS

 PR00481; LAMNOPPTDASE.