UniProt Accession

 COPG1_MOUSE; Q9QZE5; Q3U9F4; Q8BP96; Q8R1A7; Q922C6 

Genbank Protein ID

 AF187079; AK049417; AK077461; AK147895; AK151284; AK151816; AK153142; AK164280; AK169256; AK171950; AK172519; BC008553; BC024686; BC024896 

Genbank Nucleotide ID

 AAF01325.1; BAC33743.1; BAC36811.1; BAE28212.1; BAE30269.1; BAE30713.1; BAE31753.1; BAE37716.1; BAE41019.1; BAE42743.1; BAE43046.1; AAH08553.1; AAH24686.1; AAH24896.1 

Protein Name

 Coatomer subunit gamma-1 

Protein Synonyms/Alias

 Gamma-1-coat protein; Gamma-1-COP 

Gene Name

 Copg1 

Gene Synonyms/Alias

 Copg 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
213	NDRLAVSKMISKFTR	acetylation	[1]
317	TLNKVAMKHPSAVTA	acetylation	[1]
389	AISALCQKYPRKHAV	acetylation	[1]
538	YLNVLEQKQKALNAG	ubiquitination	[2]
540	NVLEQKQKALNAGYI	ubiquitination	[2]
572	YTLEPSEKPFDLKSV	acetylation	[3]
572	YTLEPSEKPFDLKSV	ubiquitination	[2]
600	STATAAVKQPEKVAA	ubiquitination	[2]
604	AAVKQPEKVAATRQE	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis. 

Sequence Annotation

 REPEAT 64 101 HEAT 1.
 REPEAT 283 320 HEAT 2.
 REPEAT 322 355 HEAT 3.
 REPEAT 356 392 HEAT 4.
 REGION 609 874 Interaction with ZNF289/ARFGAP2 (By  

Keyword

 Complete proteome; Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus; Membrane; Protein transport; Reference proteome; Repeat; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 874 AA 

Protein Sequence

Gene Ontology

 GO:0030126; C:COPI vesicle coat; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0051683; P:establishment of Golgi localization; IEA:Compara.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0072384; P:organelle transport along microtubule; IEA:Compara.
 GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW. 

Interpro

 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR002553; Clathrin/coatomer_adapt-like_N.
 IPR015873; Clathrin_a/coatomer_app_sub_C.
 IPR009028; Coatomer/calthrin_app_sub_C.
 IPR013041; Coatomer/clathrin_app_Ig-like.
 IPR017106; Coatomer_gsu.
 IPR014863; Coatomer_gsu_app.
 IPR013040; Coatomer_gsu_app_Ig-like-sub. 

Pfam

 PF01602; Adaptin_N
 PF08752; Gamma-COP 

SMART

  

PROSITE

 PS50077; HEAT_REPEAT 

PRINTS