CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007507
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 V-type proton ATPase subunit H 
Protein Synonyms/Alias
 V-ATPase subunit H; V-ATPase 54 kDa subunit; Vacuolar proton pump subunit H 
Gene Name
 VMA13 
Gene Synonyms/Alias
 CLS11; YPR036W; YP3085.02 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
53ALESILVKKNIGDGLacetylation[1]
163HNVKLVEKLLKNNNLacetylation[1]
208DVIWLHEKKFMPTLFacetylation[1]
467RVKYEALKATQAIIGubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Vacuolar ATPases regulate the organelle acidity. This subunit is essential for activity, but not assembly, of the enzyme complex. 
Sequence Annotation
  
Keyword
 3D-structure; Complete proteome; Hydrogen ion transport; Ion transport; Membrane; Reference proteome; Transport; Vacuole. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 478 AA 
Protein Sequence
MGATKILMDS THFNEIRSII RSRSVAWDAL ARSEELSEID ASTAKALESI LVKKNIGDGL 60
SSSNNAHSGF KVNGKTLIPL IHLLSTSDNE DCKKSVQNLI AELLSSDKYG DDTVKFFQED 120
PKQLEQLFDV SLKGDFQTVL ISGFNVVSLL VQNGLHNVKL VEKLLKNNNL INILQNIEQM 180
DTCYVCIRLL QELAVIPEYR DVIWLHEKKF MPTLFKILQR ATDSQLATRI VATNSNHLGI 240
QLQYHSLLLI WLLTFNPVFA NELVQKYLSD FLDLLKLVKI TIKEKVSRLC ISIILQCCST 300
RVKQHKKVIK QLLLLGNALP TVQSLSERKY SDEELRQDIS NLKEILENEY QELTSFDEYV 360
AELDSKLLCW SPPHVDNGFW SDNIDEFKKD NYKIFRQLIE LLQAKVRNGD VNAKQEKIII 420
QVALNDITHV VELLPESIDV LDKTGGKADI MELLNHSDSR VKYEALKATQ AIIGYTFK 478 
Gene Ontology
 GO:0000329; C:fungal-type vacuole membrane; TAS:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0000221; C:vacuolar proton-transporting V-type ATPase, V1 domain; TAS:SGD.
 GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; TAS:SGD.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
 GO:0007035; P:vacuolar acidification; TAS:SGD. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR004908; ATPase_V1-cplx_hsu.
 IPR011987; ATPase_V1-cplx_hsu_C. 
Pfam
 PF11698; V-ATPase_H_C
 PF03224; V-ATPase_H_N 
SMART
  
PROSITE
  
PRINTS