CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025408
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myosin-binding protein C, cardiac-type 
Protein Synonyms/Alias
  
Gene Name
 Mybpc3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
14LKMPEPGKKPVSAFNubiquitination[1]
95AVIAGSSKVKFDLKVubiquitination[1]
110TEPAPPEKAESEVAPubiquitination[1]
191VAGASLLKPPVVKWFubiquitination[1]
306LDFSSLLKKRDSFRRubiquitination[1]
316DSFRRDSKLEAPAEEubiquitination[1]
384YQVNKGHKIRLTVELubiquitination[1]
399ADPDAEVKWLKNGQEubiquitination[1]
402DAEVKWLKNGQEIQMubiquitination[1]
422IFESVGAKRTLTISQubiquitination[1]
454CSTELFVKEPPVLITubiquitination[1]
492GAQVKWLKDGVELTRubiquitination[1]
547AELIVQEKKLEVYQSubiquitination[1]
548ELIVQEKKLEVYQSIubiquitination[1]
569AKDQAVFKCEVSDENubiquitination[1]
696KTVTQGKKASTGPHPubiquitination[1]
719DEEWVFDKKLLCETEubiquitination[1]
720EEWVFDKKLLCETEGubiquitination[1]
936ERTSMLVKDLPTGARubiquitination[1]
963PGGPIVTKEPVTVQEubiquitination[1]
1004LLIPFQGKPRPQVTWubiquitination[1]
1154NMVGSSDKAAATKEPubiquitination[1]
1159SDKAAATKEPVFIPRubiquitination[1]
1175GITYEPPKYKALDFSubiquitination[1]
1177TYEPPKYKALDFSEAubiquitination[1]
1220KPKISWFKNGLDLGEubiquitination[1]
1236ARFRMFCKQGVLTLEubiquitination[1]
1246VLTLEIRKPCPYDGGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1278 AA 
Protein Sequence
MPGVTVLKMP EPGKKPVSAF NKKPRSAEVT AGSAAVFEAE TERSGVKVRW QRDGSDITAN 60
DKYGLAAEGK RHTLTVRDAS PDDQGSYAVI AGSSKVKFDL KVTEPAPPEK AESEVAPGAP 120
KEVPAPATEL EESVSSPEGS VSVTQDGSAA EHQGAPDDPI GLFLMRPQDG EVTVGGSIVF 180
SARVAGASLL KPPVVKWFKG KWVDLSSKVG QHLQLHDSYD RASKVYLFEL HITDAQTTSA 240
GGYRCEVSTK DKFDSCNFNL TVHEAIGSGD LDLRSAFRRT SLAGAGRRTS DSHEDAGTLD 300
FSSLLKKRDS FRRDSKLEAP AEEDVWEILR QAPPSEYERI AFQHGVTDLR GMLKRLKGMK 360
QDEKKSTAFQ KKLEPAYQVN KGHKIRLTVE LADPDAEVKW LKNGQEIQMS GSKYIFESVG 420
AKRTLTISQC SLADDAAYQC VVGGEKCSTE LFVKEPPVLI TRSLEDQLVM VGQRVEFECE 480
VSEEGAQVKW LKDGVELTRE ETFKYRFKKD GRKHHLIINE ATLEDAGHYA VRTSGGQSLA 540
ELIVQEKKLE VYQSIADLAV GAKDQAVFKC EVSDENVRGV WLKNGKELVP DNRIKVSHIG 600
RVHKLTIDDV TPADEADYSF VPEGFACNLS AKLHFMEVKI DFVPRQEPPK IHLDCPGSTP 660
DTIVVVAGNK LRLDVPISGD PAPTVVWQKT VTQGKKASTG PHPDAPEDAG ADEEWVFDKK 720
LLCETEGRVR VETTKDRSVF TVEGAEKEDE GVYTVTVKNP VGEDQVNLTV KVIDVPDAPA 780
APKISNVGED SCTVQWEPPA YDGGQPVLGY ILERKKKKSY RWMRLNFDLL RELSHEARRM 840
IEGVAYEMRV YAVNAVGMSR PSPASQPFMP IGPPGEPTHL AVEDVSDTTV SLKWRPPERV 900
GAGGLDGYSV EYCQEGCSEW TPALQGLTER TSMLVKDLPT GARLLFRVRA HNVAGPGGPI 960
VTKEPVTVQE ILQRPRLQLP RHLRQTIQKK VGEPVNLLIP FQGKPRPQVT WTKEGQPLAG 1020
EEVSIRNSPT DTILFIRAAR RTHSGTYQVT VRIENMEDKA TLILQIVDKP SPPQDIRIVE 1080
TWGFNVALEW KPPQDDGNTE IWGYTVQKAD KKTMEWFTVL EHYRRTHCVV SELIIGNGYY 1140
FRVFSHNMVG SSDKAAATKE PVFIPRPGIT YEPPKYKALD FSEAPSFTQP LANRSIIAGY 1200
NAILCCAVRG SPKPKISWFK NGLDLGEDAR FRMFCKQGVL TLEIRKPCPY DGGVYVCRAT 1260
NLQGEAQCEC RLEVRVPQ 1278 
Gene Ontology
 GO:0031672; C:A band; IDA:MGI.
 GO:0005856; C:cytoskeleton; TAS:MGI.
 GO:0005863; C:striated muscle myosin thick filament; IEA:Compara.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:MGI.
 GO:0008307; F:structural constituent of muscle; IEA:Compara.
 GO:0060048; P:cardiac muscle contraction; IMP:MGI.
 GO:0003007; P:heart morphogenesis; IMP:MGI.
 GO:0031034; P:myosin filament assembly; IMP:MGI.
 GO:0002027; P:regulation of heart rate; IMP:MGI.
 GO:0006942; P:regulation of striated muscle contraction; IEA:Compara.
 GO:0045214; P:sarcomere organization; IMP:MGI.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Compara. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2. 
Pfam
 PF00041; fn3
 PF07679; I-set 
SMART
 SM00060; FN3
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE 
PRINTS