CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010097
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Probable NADH oxidase 
Protein Synonyms/Alias
 NOXase 
Gene Name
 nox 
Gene Synonyms/Alias
 MPN_394; MP444 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
25RTLLSKSKDFQVNAYacetylation[1]
93DKKQVIVKDLATGKEacetylation[1]
165IDSFRHDKSIKSVAIacetylation[1]
241GFIVDADKNVVKGVEacetylation[1]
406RFKLIYDKKTLRLLGacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Catalyzes the four-electron reduction of molecular oxygen to water (By similarity). 
Sequence Annotation
 NP_BIND 8 12 FAD (By similarity).
 NP_BIND 111 114 FAD (By similarity).
 NP_BIND 170 185 NAD (By similarity).
 NP_BIND 295 305 FAD (By similarity).
 ACT_SITE 11 11 Proton acceptor (By similarity).
 ACT_SITE 43 43 Redox-active.
 BINDING 43 43 FAD (By similarity).
 BINDING 197 197 NAD (By similarity).
 BINDING 264 264 NAD; via amide nitrogen (By similarity).
 BINDING 323 323 FAD; via amide nitrogen (By similarity).
 MOD_RES 43 43 Cysteine sulfenic acid (-SOH) (By  
Keyword
 Complete proteome; FAD; Flavoprotein; NAD; Oxidation; Oxidoreductase; Redox-active center; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 479 AA 
Protein Sequence
MKKVIVIGVN HAGTSFIRTL LSKSKDFQVN AYDRNTNISF LGCGIALAVS GVVKNTEDLF 60
YSTPEELKAM GANVFMAHDV VGLDLDKKQV IVKDLATGKE TVDHYDQLVV ASGAWPICMN 120
VENEVTHTQL QFNHTDKYCG NIKNLISCKL YQHALTLIDS FRHDKSIKSV AIVGSGYIGL 180
ELAEAAWQCG KQVTVIDMLD KPAGNNFDEE FTNELEKAMK KAGINLMMGS AVKGFIVDAD 240
KNVVKGVETD KGRVDADLVI QSIGFRPNTQ FVPKDRQFEF NRNGSIKVNE YLQALNHENV 300
YVIGGAAAIY DAASEQYENI DLATNAVKSG LVAAMHMIGS KAVKLESIVG TNALHVFGLN 360
LAATGLTEKR AKMNGFDVGV SIVDDNDRPE FMGTFDKVRF KLIYDKKTLR LLGAQLLSWN 420
TNHSEIIFYI ALAVQKKMLI SELGLVDVYF LPHYNKPFNF VLAAVLQALG FSYYTPKNK 479 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0003954; F:NADH dehydrogenase activity; IEA:EC.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro. 
Interpro
 IPR016156; FAD/NAD-linked_Rdtase_dimer.
 IPR013027; FAD_pyr_nucl-diS_OxRdtase.
 IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
 IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD.
 IPR001327; Pyr_OxRdtase_NAD-bd_dom. 
Pfam
 PF00070; Pyr_redox
 PF07992; Pyr_redox_2
 PF02852; Pyr_redox_dim 
SMART
  
PROSITE
  
PRINTS
 PR00368; FADPNR.