CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035259
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adenylosuccinate lyase (Predicted) 
Protein Synonyms/Alias
 Protein Adsl 
Gene Name
 Adsl 
Gene Synonyms/Alias
 Adsl_predicted; rCG_60301 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
35FLFSDRYKFQTWRQLacetylation[1]
147SRLADFAKERADLPTacetylation[1]
295GSSAMPYKRNPMRSEacetylation[1]
415QQAAAVVKQEGGDNDacetylation[1]
470EEVYPLLKPYGSVMAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lyase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 484 AA 
Protein Sequence
MAASGDPACA ESYRSPLAAR YASHEMCFLF SDRYKFQTWR QLWLWLAEAE QTLGLPITDE 60
QIQEMRSNLS NIDFQMAAEE EKRLRHDVMA HVHTFGHCCP KAAGIIHLGA TSCYVGDNTD 120
LIILRNAFDL LLPKLARVIS RLADFAKERA DLPTLGFTHF QPAQLTTVGK RCCLWIQDLC 180
MDLQNLKRVR DELRFRGVKG TTGTQASFLQ LFEGDHQKVE QLDKMVTEKA GFKRAYIITG 240
QTYTRKVDIE VLSVLASLGA SVHKICTDIR LLANLKEMEE PFEKQQIGSS AMPYKRNPMR 300
SERCCSLARH LMSLTMDPLQ TASVQWFERT LDDSANRRIC LAEAFLTADT ILTTLQNVSE 360
GLVLYPKVIE RRIRQELPFM ATENIIMAMV KAGGSRQDCH EKIRVLSQQA AAVVKQEGGD 420
NDLIERIRAD AYFSPIHSQL EQLLDPSSFT GRAPQQVHRF LEEEVYPLLK PYGSVMAVKA 480
ELCL 484 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0070626; F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity; IDA:RGD.
 GO:0004018; F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; IDA:RGD.
 GO:0009060; P:aerobic respiration; IMP:RGD.
 GO:0006167; P:AMP biosynthetic process; IDA:RGD.
 GO:0051262; P:protein tetramerization; IDA:RGD.
 GO:0001666; P:response to hypoxia; IEP:RGD.
 GO:0014850; P:response to muscle activity; IEP:RGD.
 GO:0007584; P:response to nutrient; IDA:RGD.
 GO:0042594; P:response to starvation; IEP:RGD. 
Interpro
 IPR019468; AdenyloSucc_lyase_C.
 IPR003031; D_crystallin.
 IPR024083; Fumarase/histidase_N.
 IPR000362; Fumarate_lyase.
 IPR020557; Fumarate_lyase_CS.
 IPR022761; Fumarate_lyase_N.
 IPR008948; L-Aspartase-like.
 IPR004769; Pur_lyase. 
Pfam
 PF10397; ADSL_C
 PF00206; Lyase_1 
SMART
 SM00998; ADSL_C 
PROSITE
 PS00163; FUMARATE_LYASES 
PRINTS
 PR00145; ARGSUCLYASE.
 PR00149; FUMRATELYASE.