CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013054
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 E3 ubiquitin-protein ligase RNF149 
Protein Synonyms/Alias
 Goliath-related E3 ubiquitin-protein ligase 4; RING finger protein 149 
Gene Name
 Rnf149 
Gene Synonyms/Alias
 Greul4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
241NHRKETKKVIGQLPLubiquitination[1]
311MCKLDVIKALGYWGDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation (By similarity). 
Sequence Annotation
 DOMAIN 66 171 PA.
 ZN_FING 265 306 RING-type; atypical.
 CARBOHYD 51 51 N-linked (GlcNAc...) (Potential).
 CARBOHYD 141 141 N-linked (GlcNAc...) (Potential).
 CARBOHYD 339 339 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Glycoprotein; Ligase; Membrane; Metal-binding; Reference proteome; Signal; Transmembrane; Transmembrane helix; Ubl conjugation pathway; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 394 AA 
Protein Sequence
MAARRRPAAG VGARDALAVL ALALCTPGVG GGALEWYSAM VSIEYVDPQS NLTVWSVSES 60
GRFGESSLRE ERQGLVGVPR APAPAEGCAP DTRFVAPGAL GNAPWVALVA RGGCTFKDKV 120
LAAARRNASA VVVYNLESNG NATEPMSHAG TGNIVVIMIS YPKGREIFDL VQKGIPVKMR 180
IEIGTRHMQE FISGQSVVFV AIAFITMMII SLAWLIFYYI QRFLYTGSQF GSQNHRKETK 240
KVIGQLPLHT VKHGEKGIDV DAENCAVCIE NFKVKDVIRI LPCKHIFHRI CIDPWLLDHR 300
TCPMCKLDVI KALGYWGDPE DTQELPTPEA APGRVSVGNL SVTSQDEERS ESNLPSSSSS 360
ESGPHRPCLK EDAGEDTALL GAGRSEPQHG GSIC 394 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. 
Interpro
 IPR003137; Protease-assoc_domain.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF02225; PA
 PF13639; zf-RING_2 
SMART
 SM00184; RING 
PROSITE
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS