| Tag | Content |
|---|
| CPLM ID | CPLM-006222 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cell division control protein 13 |
Protein Synonyms/Alias | |
Gene Name | CDC13 |
Gene Synonyms/Alias | YDL220C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 909 | AQNGVTVKKEEDNDD | sumoylation | [1] |
|
Reference | [1] SUMOylation regulates telomere length homeostasis by targeting Cdc13. Hang LE, Liu X, Cheung I, Yang Y, Zhao X. Nat Struct Mol Biol. 2011 Jul 10;18(8):920-6. [ PMID: 21743457] |
Functional Description | Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity. |
Sequence Annotation | DNA_BIND 500 686 OB.
MOD_RES 306 306 Phosphoserine.
MOD_RES 308 308 Phosphothreonine. |
Keyword | 3D-structure; Cell cycle; Cell division; Chromosome; Complete proteome; DNA-binding; Phosphoprotein; Reference proteome; Telomere. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 924 AA |
Protein Sequence | MDTLEEPECP PHKNRIFVSS SKDFEGYPSK AIVPVQFVAL LTSIHLTETK CLLGFSNFER 60
RGDQSQEDQY LIKLKFKDRG SERLARITIS LLCQYFDIEL PDLDSDSGAS PTVILRDIHL 120
ERLCFSSCKA LYVSKHGNYT LFLEDIKPLD LVSVISTIST KSTNSSKHSS SELISECDLN 180
NSLVDIFNNL IEMNRDEKNR FKFVKLIHYD IELKKFVQDQ QKVLSQKSKA AAINPFFVPN 240
RLGIPYIESQ NEFNSQLMTL NVDEPTTDIS NMGEEMHDSA DPIEDSDSST TSSTGKYFSS 300
KSYIQSQTPE RKTSVPNNWH DDDSGSKRKR KLSFHSPNAS SIRKAISYEQ LSLASVGSVE 360
RLEGKIVGMN PPQFASINEF KYCTLKLYFT QLLPNVPDKV LVPGVNCIEI VIPTRERICE 420
LFGVLNCQSD KISDILLLEK PDRISVEVER ILWDNDKTAS PGMAVWSLKN ISTDTQAQAQ 480
VQVPAQSSAS IDPSRTRMSK MARKDPTIEF CQLGLDTFET KYITMFGMLV SCSFDKPAFI 540
SFVFSDFTKN DIVQNYLYDR YLIDYENKLE LNEGFKAIMY KNQFETFDSK LRKIFNNGLR 600
DLQNGRDENL SQYGIVCKMN IKVKMYNGKL NAIVRECEPV PHSQISSIAS PSQCEHLRLF 660
YQRAFKRIGE SAISRYFEEY RRFFPIHRNG SHLAKLRFDE VKHEPKKSPT TPALAEHIPD 720
LNADVSSFDV KFTDISSLLD SSARLPRPQQ THKSNTLYSC EGRIIAIEYH ASDLCFHITN 780
ELPLLQTRGL APERVLQLHI ITSKNFAYFF NRSSAYLQRQ PLEEKYTQLA QFLGHSFKFN 840
ITSSLTLFPD TTVALQIWCP IECTFRELQQ QLAHPKVAAA PDSGSLDCAI NATVNPLRLL 900
AAQNGVTVKK EEDNDDDAGA VPTS 924 |
Gene Ontology | GO:0000783; C:nuclear telomere cap complex; IDA:SGD. GO:0043047; F:single-stranded telomeric DNA binding; IDA:SGD. GO:0010521; F:telomerase inhibitor activity; IDA:SGD. GO:0007049; P:cell cycle; IEA:UniProtKB-KW. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0032210; P:regulation of telomere maintenance via telomerase; IGI:SGD. GO:0016233; P:telomere capping; IMP:SGD. GO:0007004; P:telomere maintenance via telomerase; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |