CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019465
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RING finger protein 145 
Protein Synonyms/Alias
  
Gene Name
 RNF145 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
535LRAQLGWKSFLLRRDubiquitination[1, 2]
548RDAVNKIKSLPIATKubiquitination[1]
555KSLPIATKEQLEKHNubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
 ZN_FING 537 575 RING-type; atypical.  
Keyword
 Alternative splicing; Complete proteome; Membrane; Metal-binding; Reference proteome; Transmembrane; Transmembrane helix; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 663 AA 
Protein Sequence
MMRNHRIASS LCGDQVFSKK KKKKKKNNMA AKEKLEAVLN VALRVPSIML LDVLYRWDVS 60
SFFQQIQRSS LSNNPLFQYK YLALNMHYVG YILSVVLLTL PRQHLVQLYL YFLTALLLYA 120
GHQISRDYVR SELEFAYEGP MYLEPLSMNR FTTALIGQLV VCTLCSCVMK TKQIWLFSAH 180
MLPLLARLCL VPLETIVIIN KFAMIFTGLE VLYFLGSNLL VPYNLAKSAY RELVQVVEVY 240
GLLALGMSLW NQLVVPVLFM VFWLVLFALQ IYSYFSTRDQ PASRERLLFL FLTSIAECCS 300
TPYSLLGLVF TVSFVALGVL TLCKFYLQGY RAFMNDPAMN RGMTEGVTLL ILAVQTGLIE 360
LQVVHRAFLL SIILFIVVAS ILQSMLEIAD PIVLALGASR DKSLWKHFRA VSLCLFLLVF 420
PAYMAYMICQ FFHMDFWLLI IISSSILTSL QVLGTLFIYV LFMVEEFRKE PVENMDDVIY 480
YVNGTYRLLE FLVALCVVAY GVSETIFGEW TVMGSMIIFI HSYYNVWLRA QLGWKSFLLR 540
RDAVNKIKSL PIATKEQLEK HNDICAICYQ DMKSAVITPC SHFFHAGCLK KWLYVQETCP 600
LCHCHLKNSS QLPGLGTEPV LQPHAGAEQN VMFQEGTEPP GQEHTPGTRI QEGSRDNNEY 660
IARRPDNQEG AFDPKEYPHS AKDEAHPVES A 691 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR025754; TRC8_N_dom.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF13705; TRC8_N
 PF13639; zf-RING_2 
SMART
 SM00184; RING 
PROSITE
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS