CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013805
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Oxysterol-binding protein 2 
Protein Synonyms/Alias
  
Gene Name
 Osbp2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
722VPYSYFSKEAARKVTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Binds 7-ketocholesterol (By similarity). 
Sequence Annotation
 DOMAIN 179 271 PH.  
Keyword
 Complete proteome; Lipid transport; Lipid-binding; Membrane; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 908 AA 
Protein Sequence
MGKAAALSRG GGCAGRSRGL SSLFTVVPCL SCHTAAPGMN SSAFGSGPAS KPQLQPVQAP 60
ERELLSKQVC QPISEPASRS EPGSQTTSVP RPSGVGQESE LQGLWPGSEN GTRSVSIIKA 120
SPELAMPSPL QSTVGSLPVT KPESKLVPKT QSFLRQGQAK ISVGTPVSGI GVQMVSPPLD 180
SYKGWLLKWT NYLKGYQRRW FVLGNGLLSY YRNQGEMAHT CRATINLAST HFETEDSCGI 240
LLCNGARTYH LKASSEVDRQ HWITALELAK AKAIRVMKTQ SDDSGDDDEE PAAPADNSEL 300
HHTLKTLSLK LNDLSTCNDL IAKHGAALQR SLNELDSLKI PSECGEKLKV VNERATLFRI 360
TSNAMINACR DFLELAETHS RKWQRALNYE QEQRVHLEET IEQLAKQHNS LERAFCNTPG 420
GPASSSKSFS EGSFLTSKGE NSEEDEDTEY FDAMEDSTSF ITVVTEAKED RKPESGPGTT 480
TVDWTSADNV LDGASFMPKN SCKVKRRVRI PDKPNYSLNL WSIMKNCIGR ELSRIPMPVN 540
FNEPLSMLQR LTEDLEYHHL LDKAVNCTSS VEQMCLVAAF SVSSYSTTVH RIAKPFNPML 600
GETFELDRME DMGLRSLCEQ VSHHPPSAAH HVFSKHGWSL WQEITIASKF RGKYISIMPL 660
GAIHLEFQAS GNHYVWRKST STVHNIIVGK LWIDQSGDIE IVNHKTKDRC QLKFVPYSYF 720
SKEAARKVTG VVSDSQGKAH YVLSGSWDDQ MECSKIVHSS PSSDGRQKTV YQTLPAKLLW 780
RKYPLPENAE NMYYFSELAL TLNEQEDGVA PTDSRLRPDQ RLMERGRWDE ANTEKQRLEE 840
KQRLSRRRRL ESCTAGCGGE EEKESDGYVP LWFEKRLDPL TGEMACMYKG GYWEAKEKKD 900
WHMCPNIF 908 
Gene Ontology
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0015485; F:cholesterol binding; IEA:Compara.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0006869; P:lipid transport; IEA:UniProtKB-KW. 
Interpro
 IPR000648; Oxysterol-bd.
 IPR018494; Oxysterol-bd_CS.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF01237; Oxysterol_BP
 PF00169; PH 
SMART
 SM00233; PH 
PROSITE
 PS01013; OSBP
 PS50003; PH_DOMAIN 
PRINTS