UniProt Accession

 D6RD96_HUMAN; D6RD96 

Genbank Protein ID

 AL118496; AL138968 

Genbank Nucleotide ID

  

Protein Name

 Long-chain-fatty-acid--CoA ligase 4 

Protein Synonyms/Alias

  

Gene Name

 ACSL4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
49	MAKRIKAKPTSDKPG	ubiquitination	[1]
54	KAKPTSDKPGSPYRS	ubiquitination	[1]
89	LFDHAVSKFGKKDSL	ubiquitination	[2]
113	NEMQPNGKVFKKLIL	ubiquitination	[1, 2, 3]
124	KLILGNYKWMNYLEV	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 145 AA 

Protein Sequence

Gene Ontology

 GO:0031966; C:mitochondrial membrane; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005777; C:peroxisome; IEA:Compara.
 GO:0004467; F:long-chain fatty acid-CoA ligase activity; IEA:Compara.
 GO:0060996; P:dendritic spine development; IEA:Compara.
 GO:0060136; P:embryonic process involved in female pregnancy; IEA:Compara.
 GO:0015908; P:fatty acid transport; IEA:Compara.
 GO:0070672; P:response to interleukin-15; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0006641; P:triglyceride metabolic process; IEA:Compara. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS