UniProt Accession

 STAT_DROME; Q24151; Q0KI43; Q24181; Q59DV7; Q5BIB0; Q8IN54; Q8SX55; Q9VDL8 

Genbank Protein ID

 U40070; U46688; AE014297; AE014297; AE014297; AE014297; BT021314; AY094839 

Genbank Nucleotide ID

 AAC46984.1; AAB02195.1; AAN14350.2; AAN14351.2; AAS65180.1; AAX52969.1; AAX33462.1; AAM11192.1 

Protein Name

 Signal transducer and transcription activator 

Protein Synonyms/Alias

 d-STAT; Protein marelle 

Gene Name

 Stat92E 

Gene Synonyms/Alias

 MARE; mrL; Stat; CG4257 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
187	ALGMVTPKVELYEVQ	sumoylation	[1]

Reference

 [1] Sumoylation of Drosophila transcription factor STAT92E.
 Grönholm J, Ungureanu D, Vanhatupa S, Rämet M, Silvennoinen O.
 J Innate Immun. 2010;2(6):618-24. [PMID: 20616536] 

Functional Description

 Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression. The Janus kinase-STAT pathway is connected to drosophila early development. 

Sequence Annotation

 DOMAIN 594 658 SH2.
 MOD_RES 711 711 Phosphotyrosine; by JAK.  

Keyword

 Activator; Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; SH2 domain; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 761 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:FlyBase.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0003677; F:DNA binding; TAS:FlyBase.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:FlyBase.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0007350; P:blastoderm segmentation; IMP:FlyBase.
 GO:0007298; P:border follicle cell migration; IMP:FlyBase.
 GO:0071222; P:cellular response to lipopolysaccharide; IDA:FlyBase.
 GO:0071481; P:cellular response to X-ray; IMP:FlyBase.
 GO:0048749; P:compound eye development; TAS:FlyBase.
 GO:0006952; P:defense response; IDA:FlyBase.
 GO:0007425; P:epithelial cell fate determination, open tracheal system; TAS:FlyBase.
 GO:0007455; P:eye-antennal disc morphogenesis; IMP:FlyBase.
 GO:0042078; P:germ-line stem cell division; TAS:FlyBase.
 GO:0030718; P:germ-line stem cell maintenance; IMP:FlyBase.
 GO:0035172; P:hemocyte proliferation; TAS:FlyBase.
 GO:0007442; P:hindgut morphogenesis; IMP:FlyBase.
 GO:0006959; P:humoral immune response; TAS:FlyBase.
 GO:0007476; P:imaginal disc-derived wing morphogenesis; NAS:FlyBase.
 GO:0007259; P:JAK-STAT cascade; TAS:FlyBase.
 GO:0035171; P:lamellocyte differentiation; NAS:FlyBase.
 GO:0007616; P:long-term memory; IMP:FlyBase.
 GO:0008348; P:negative regulation of antimicrobial humoral response; IMP:FlyBase.
 GO:0030178; P:negative regulation of Wnt receptor signaling pathway; IMP:FlyBase.
 GO:0007399; P:nervous system development; IMP:FlyBase.
 GO:0030720; P:oocyte localization involved in germarium-derived egg chamber formation; IMP:FlyBase.
 GO:0030713; P:ovarian follicle cell stalk formation; IMP:FlyBase.
 GO:0008284; P:positive regulation of cell proliferation; IMP:FlyBase.
 GO:0007538; P:primary sex determination; IMP:FlyBase.
 GO:0046425; P:regulation of JAK-STAT cascade; IMP:FlyBase.
 GO:0007379; P:segment specification; IMP:FlyBase.
 GO:0048103; P:somatic stem cell division; TAS:FlyBase.
 GO:0035019; P:somatic stem cell maintenance; IMP:FlyBase. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR008967; p53-like_TF_DNA-bd.
 IPR000980; SH2.
 IPR013800; STAT_TF_alpha.
 IPR015988; STAT_TF_coiled-coil.
 IPR001217; STAT_TF_core.
 IPR013801; STAT_TF_DNA-bd.
 IPR012345; STAT_TF_DNA-bd_sub.
 IPR013799; STAT_TF_prot_interaction. 

Pfam

 PF00017; SH2
 PF01017; STAT_alpha
 PF02864; STAT_bind
 PF02865; STAT_int 

SMART

 SM00252; SH2 

PROSITE

 PS50001; SH2 

PRINTS