CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003385
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcriptional regulatory protein CusR 
Protein Synonyms/Alias
  
Gene Name
 cusR 
Gene Synonyms/Alias
 ylcA; b0571; JW0560 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
10LLIVEDEKKTGEYLTacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618
Functional Description
 Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA and plasmid pRJ1004 gene pcoE in response to increasing levels of copper ions, and probably silver ions. Can also increase the basal-level expression of copper resistance gene operon pcoABCD. 
Sequence Annotation
 DOMAIN 1 116 Response regulatory.
 MOD_RES 51 51 4-aspartylphosphate (By similarity).  
Keyword
 Activator; Complete proteome; Copper; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Two-component regulatory system. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 227 AA 
Protein Sequence
MKLLIVEDEK KTGEYLTKGL TEAGFVVDLA DNGLNGYHLA MTGDYDLIIL DIMLPDVNGW 60
DIVRMLRSAN KGMPILLLTA LGTIEHRVKG LELGADDYLV KPFAFAELLA RVRTLLRRGA 120
AVIIESQFQV ADLMVDLVSR KVTRSGTRIT LTSKEFTLLE FFLRHQGEVL PRSLIASQVW 180
DMNFDSDTNA IDVAVKRLRG KIDNDFEPKL IQTVRGVGYM LEVPDGQ 227 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0032993; C:protein-DNA complex; IDA:EcoCyc.
 GO:0001114; C:protein-DNA-RNA complex; IDA:EcoCyc.
 GO:0001046; F:core promoter sequence-specific DNA binding; IDA:EcoCyc.
 GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:GOC.
 GO:0000160; P:phosphorelay signal transduction system; IDA:EcoCyc.
 GO:0010628; P:positive regulation of gene expression; IMP:EcoCyc.
 GO:0006355; P:regulation of transcription, DNA-dependent; IMP:EcoCyc.
 GO:0046688; P:response to copper ion; IMP:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR011006; CheY-like_superfamily.
 IPR001867; Sig_transdc_resp-reg_C.
 IPR006291; Sig_transdc_resp-reg_metal.
 IPR001789; Sig_transdc_resp-reg_receiver.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00072; Response_reg
 PF00486; Trans_reg_C 
SMART
 SM00448; REC
 SM00862; Trans_reg_C 
PROSITE
 PS50110; RESPONSE_REGULATORY 
PRINTS