| Tag | Content |
|---|
| CPLM ID | CPLM-022712 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase RNF25 |
Protein Synonyms/Alias | RING finger protein 25; RING finger protein AO7 |
Gene Name | Rnf25 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 119 | MLYELIEKGKEILTD | ubiquitination | [1] | | 331 | QRPGETQKSVLDPPR | ubiquitination | [1] | | 353 | QYDRRHPKGGECCTP | ubiquitination | [1] | | 361 | GGECCTPKGTSEIHE | ubiquitination | [1] | | 374 | HELPPPEKPLKETVD | ubiquitination | [1] | | 377 | PPPEKPLKETVDLKA | ubiquitination | [1] | | 398 | LTGHPQEKGPGSWQG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2. Stimulates transcription mediated by NF-kappa-B (By similarity). |
Sequence Annotation | DOMAIN 18 127 RWD.
ZN_FING 134 199 RING-type. |
Keyword | Complete proteome; Ligase; Metal-binding; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 456 AA |
Protein Sequence | MAASASTAAG EEDWVLPSEV EVLESIYLDE LQVMKGNGRS PWEIFITLHP ATAEVQDSQF 60
VCFTLVLRIP VQYPHEVPQI SIRNPRGLSD EQIHKISQAL GHVAKEGLGT AMLYELIEKG 120
KEILTDNNIP HGQCVICLYG FQEKEAFTKT PCYHYFHCHC LARYIQHMEQ ELTTQEQEQE 180
RQHVVTKQKA VGVQCPVCRE PLVYDLASLK AAPEPQQPME LYQPSAESLR QQEELKLLYQ 240
RQQEKGGIID LEAERNRYFI SLQQPPAALE PESAVDVSRE PQPPNALSAE QSTSLADQST 300
LPTSLPMTTQ YTYEKTSGAG PNQQRPGETQ KSVLDPPRHG RGSWRQYDRR HPKGGECCTP 360
KGTSEIHELP PPEKPLKETV DLKAEPRNKG LTGHPQEKGP GSWQGPSARR TRDCARWERS 420
KNRTPGSCYP HLPRGQGAYR SGTRREPLGL ESEEGS 456 |
Gene Ontology | GO:0005829; C:cytosol; ISS:UniProtKB. GO:0005634; C:nucleus; ISS:UniProtKB. GO:0051059; F:NF-kappaB binding; ISS:UniProtKB. GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |